The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100   2,340,659 21,470 SH   SOLE   21,470 0 0
ABBVIE INC COM 00287Y109   1,726,430 12,814 SH   SOLE   12,814 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   138,750 150,000 SH   SOLE   150,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107   409,848 3,598 SH   SOLE   3,598 0 0
AKERO THERAPEUTICS INC COM 00973Y108   2,790,988 59,777 SH   SOLE   59,777 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   1,217,650 245,000 SH   SOLE   245,000 0 0
AMGEN INC COM 031162100   303,945 1,369 SH   SOLE   1,369 0 0
ANNEXON INC COM 03589W102   2,300,260 653,483 SH   SOLE   653,483 0 0
APPLIED THERAPEUTICS INC COM 03828A101   3,049,755 2,382,621 SH   SOLE   2,382,621 0 0
ARGENX SE SPONSORED ADR 04016X101   1,197,640 3,073 SH   SOLE   3,073 0 0
ATAI LIFE SCIENCES NV SHS N0731H103   240,800 140,000 SH   SOLE   140,000 0 0
ATHIRA PHARMA INC COM 04746L104   4,403,736 1,492,792 SH   SOLE   1,492,792 0 0
ATRICURE INC COM 04963C209   575,044 11,650 SH   SOLE   11,650 0 0
AUTONATION INC COM 05329W102   2,469,150 15,000 SH Put SOLE   15,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   1,386,250 125,000 SH   SOLE   125,000 0 0
BAXTER INTL INC COM 071813109   243,792 5,351 SH   SOLE   5,351 0 0
BECTON DICKINSON & CO COM 075887109   1,520,698 5,760 SH   SOLE   5,760 0 0
BIOGEN INC COM 09062X103   851,417 2,989 SH   SOLE   2,989 0 0
BIO-TECHNE CORP COM 09073M104   377,784 4,628 SH   SOLE   4,628 0 0
BOSTON SCIENTIFIC CORP COM 101137107   638,911 11,812 SH   SOLE   11,812 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   960,500 25,000 SH   SOLE   25,000 0 0
COOPER COS INC COM NEW 216648402   1,545,606 4,031 SH   SOLE   4,031 0 0
CYBIN INC COM 23256X100   189,000 500,000 SH   SOLE   500,000 0 0
DEXCOM INC COM 252131107   2,192,766 17,063 SH   SOLE   17,063 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105   774,156 1,099,653 SH   SOLE   1,099,653 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   883,560 12,878 SH   SOLE   12,878 0 0
EXACT SCIENCES CORP COM 30063P105   2,078,289 22,133 SH   SOLE   22,133 0 0
FULCRUM THERAPEUTICS INC COM 359616109   2,297,777 696,296 SH   SOLE   696,296 0 0
GILEAD SCIENCES INC COM 375558103   863,955 11,210 SH   SOLE   11,210 0 0
HCA HEALTHCARE INC COM 40412C101   218,202 719 SH   SOLE   719 0 0
HERON THERAPEUTICS INC COM 427746102   326,644 281,590 SH   SOLE   281,590 0 0
HUMANA INC COM 444859102   279,903 626 SH   SOLE   626 0 0
IDEXX LABS INC COM 45168D104   716,682 1,427 SH   SOLE   1,427 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   2,090,279 6,113 SH   SOLE   6,113 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   55,671,594 150,700 SH Put SOLE   150,700 0 0
IQVIA HLDGS INC COM 46266C105   445,494 1,982 SH   SOLE   1,982 0 0
ISHARES GOLD TR ISHARES NEW 464285204   2,943,187 80,879 SH   SOLE   80,879 0 0
ISHARES INC CORE MSCI EMKT 46434G103   4,048,730 82,141 SH   SOLE   82,141 0 0
ISHARES TR CORE S&P500 ETF 464287200   312,998,510 702,247 SH   SOLE   702,247 0 0
ISHARES TR FLTG RATE NT ETF 46429B655   1,597,628 31,437 SH   SOLE   31,437 0 0
ISHARES TR 0-5YR INVT GR CP 46434V100   2,100,558 43,571 SH   SOLE   43,571 0 0
ISHARES TR IBONDS DEC23 ETF 46434VAX8   2,103,799 83,187 PRN   SOLE   83,187 0 0
ISHARES TR IBOXX HI YD ETF 464288513   1,067,195 14,216 SH   SOLE   14,216 0 0
ISHARES TR IBONDS DEC24 ETF 46434VBG4   2,103,582 85,442 PRN   SOLE   85,442 0 0
ISHARES TR MBS ETF 464288588   3,154,875 33,827 SH   SOLE   33,827 0 0
ISHARES TR CORE MSCI EAFE 46432F842   16,731,698 247,877 SH   SOLE   247,877 0 0
ISHARES TR BLACKROCK ULTRA 46434V878   2,104,200 41,833 SH   SOLE   41,833 0 0
ISHARES TR IBOXX INV CP ETF 464287242   3,183,317 29,437 SH   SOLE   29,437 0 0
ISHARES TR CORE US AGGBD ET 464287226   943,748 9,635 SH   SOLE   9,635 0 0
ISHARES TR MSCI EAFE ETF 464287465   86,644,750 1,195,100 SH Put SOLE   1,195,100 0 0
ISHARES TR MSCI EMG MKT ETF 464287234   16,259,160 411,000 SH Put SOLE   411,000 0 0
J P MORGAN EXCHANGE TRADED F ULTRA SHRT INC 46641Q837   1,601,572 31,942 SH   SOLE   31,942 0 0
JOHNSON & JOHNSON COM 478160104   3,933,252 23,763 SH   SOLE   23,763 0 0
KAYNE ANDERSON ENERGY INFRST COM 486606106   1,196,849 147,033 SH   SOLE   147,033 0 0
KURA ONCOLOGY INC COM 50127T109   846,400 80,000 SH   SOLE   80,000 0 0
KYMERA THERAPEUTICS INC COM 501575104   242,131 10,532 SH   SOLE   10,532 0 0
LEMONADE INC COM 52567D107   187,136 11,106 SH   SOLE   11,106 0 0
LILLY ELI & CO COM 532457108   2,902,517 6,189 SH   SOLE   6,189 0 0
LIVANOVA PLC SHS G5509L101   223,720 4,350 SH   SOLE   4,350 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   3,301,914 14,294 SH   SOLE   14,294 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   1,629,000 150,000 SH   SOLE   150,000 0 0
MEDTRONIC PLC SHS G5960L103   4,186,424 47,519 SH   SOLE   47,519 0 0
MERCK & CO INC COM 58933Y105   438,136 3,797 SH   SOLE   3,797 0 0
MICROSOFT CORP COM 594918104   468,242 1,375 SH   SOLE   1,375 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,810,900 70,000 SH   SOLE   70,000 0 0
NVIDIA CORPORATION COM 67066G104   12,986,714 30,700 SH Put SOLE   30,700 0 0
NVIDIA CORPORATION COM 67066G104   561,771 1,328 SH   SOLE   1,328 0 0
PENUMBRA INC COM 70975L107   1,196,985 3,479 SH   SOLE   3,479 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   3,407,229 237,935 SH   SOLE   237,935 0 0
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105   9,165,000 650,000 SH   SOLE   650,000 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   15,498,789 1,045,097 SH   SOLE   1,045,097 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   1,533,908 143,490 SH   SOLE   143,490 0 0
QUIDELORTHO CORP COM 219798105   324,645 3,918 SH   SOLE   3,918 0 0
REGENERON PHARMACEUTICALS COM 75886F107   2,672,250 3,719 SH   SOLE   3,719 0 0
REPLIMUNE GROUP INC COM 76029N106   3,483,000 150,000 SH   SOLE   150,000 0 0
REVVITY INC COM 714046109   287,709 2,422 SH   SOLE   2,422 0 0
SAGE THERAPEUTICS INC COM 78667J108   2,352,411 50,030 SH   SOLE   50,030 0 0
SANOFI SPONSORED ADR 80105N105   4,355,821 80,813 SH   SOLE   80,813 0 0
SCHWAB STRATEGIC TR US TIPS ETF 808524870   1,065,745 20,327 SH   SOLE   20,327 0 0
SERES THERAPEUTICS INC COM 81750R102   2,637,499 550,626 SH   SOLE   550,626 0 0
SIMPLIFY EXCHANGE TRADED FUN COMMODITIES STRA 82889N566   3,245,076 131,353 SH   SOLE   131,353 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   7,095,936 278,272 SH   SOLE   278,272 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798   3,006,326 204,512 SH   SOLE   204,512 0 0
SIMPLIFY EXCHANGE TRADED FUN SIMPLIFY INTERST 82889N855   3,319,995 52,883 SH   SOLE   52,883 0 0
SIMPLIFY EXCHANGE TRADED FUN HIGH YIELD PLUS 82889N830   9,821,586 449,867 SH   SOLE   449,867 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND P 82889N723   8,033,616 356,826 SH   SOLE   356,826 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   7,990,232 352,303 SH   SOLE   352,303 0 0
SIMPLIFY EXCHANGE TRADED FUN MARKET NEUTRAL 82889N541   2,461,750 100,000 SH   SOLE   100,000 0 0
SIMPLIFY EXCHANGE TRADED FUN ENHANCED INM ETF 82889N632   2,786,953 111,389 SH   SOLE   111,389 0 0
SIMPLIFY EXCHANGE TRADED FUN STABLE INCM ETF 82889N640   2,808,274 112,062 SH   SOLE   112,062 0 0
SIMPLIFY EXCHANGE TRADED FUN VOLATILITY PREM 82889N863   2,740,253 119,401 SH   SOLE   119,401 0 0
SONDER HOLDINGS INC CLASS A COM 83542D102   77,286 145,685 SH   SOLE   145,685 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   30,586,320 69,000 SH Call SOLE   69,000 0 0
SPDR SER TR PORTFOLIO SHORT 78464A474   2,101,427 71,380 SH   SOLE   71,380 0 0
SPDR SER TR BLOOMBERG INVT 78468R200   2,303,837 75,068 SH   SOLE   75,068 0 0
STOKE THERAPEUTICS INC COM 86150R107   1,305,321 122,796 SH   SOLE   122,796 0 0
STRYKER CORPORATION COM 863667101   1,368,024 4,484 SH   SOLE   4,484 0 0
SUTRO BIOPHARMA INC COM 869367102   558,000 120,000 SH   SOLE   120,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   268,092 12,809 SH   SOLE   12,809 0 0
TELESAT CORP CL A & CL B SHS 879512309   1,514,557 160,781 SH   SOLE   160,781 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   864,011 10,617 SH   SOLE   10,617 0 0
TESLA INC COM 88160R101   3,115,063 11,900 SH Call SOLE   11,900 0 0
TESLA INC COM 88160R101   487,154 1,861 SH   SOLE   1,861 0 0
THE CIGNA GROUP COM 125523100   1,864,026 6,643 SH   SOLE   6,643 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   1,699,862 3,258 SH   SOLE   3,258 0 0
TSCAN THERAPEUTICS INC COM 89854M101   2,617,290 1,046,916 SH   SOLE   1,046,916 0 0
UNITEDHEALTH GROUP INC COM 91324P102   479,198 997 SH   SOLE   997 0 0
VANGUARD BD INDEX FDS SHORT TRM BOND 921937827   3,157,567 41,865 SH   SOLE   41,865 0 0
VANGUARD SCOTTSDALE FDS MTG-BKD SECS ETF 92206C771   3,147,589 68,628 SH   SOLE   68,628 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   2,636,158 7,491 SH   SOLE   7,491 0 0
X4 PHARMACEUTICALS INC COM 98420X103   776,000 400,000 SH   SOLE   400,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   2,837,453 19,488 SH   SOLE   19,488 0 0
ZOETIS INC CL A 98978V103   248,499 1,443 SH   SOLE   1,443 0 0