The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio Inc EQUITIES 282559103   7,513,618 396,497 SH   SOLE   396,497 0 0
ANI Pharmaceuticals Inc EQUITIES 00182C103   2,909,027 54,041 SH   SOLE   54,041 0 0
Aclaris Therapeutics Inc LONG OPTION CALLS 00461U105   6,755,018 651,400 SH Call SOLE   651,400 0 0
Aclaris Therapeutics Inc EQUITIES 00461U105   2,273,405 219,229 SH   SOLE   219,229 0 0
Akero Therapeutics Inc LONG OPTION CALLS 00973Y108   11,039,820 236,500 SH Call SOLE   236,500 0 0
Akero Therapeutics Inc EQUITIES 00973Y108   11,268,958 241,357 SH   SOLE   241,357 0 0
Aligos Therapeutics Inc EQUITIES 01626L105   613,562 631,887 SH   SOLE   631,887 0 0
Alkermes Plc EQUITIES G01767105   1,252,000 40,000 SH   SOLE   40,000 0 0
Allakos Inc EQUITIES 01671P100   872,000 200,000 SH   SOLE   200,000 0 0
Ambrx Biopharma Inc EQUITIES 02290A102   1,646,000 100,000 SH   SOLE   100,000 0 0
Annexon Inc EQUITIES 03589W102   1,372,487 389,911 SH   SOLE   389,911 0 0
BioCryst Pharmaceuticals Inc EQUITIES 09058V103   5,356,764 760,904 SH   SOLE   760,904 0 0
BioMarin Pharmaceutical Inc EQUITIES 09061G101   866,800 10,000 SH   SOLE   10,000 0 0
Biogen Idec Inc EQUITIES 09062X103   7,649,362 26,854 SH   SOLE   26,854 0 0
Biohaven Ltd EQUITIES G1110E107   478,400 20,000 SH   SOLE   20,000 0 0
Bridgebio Pharma Inc EQUITIES 10806X102   860,000 50,000 SH   SOLE   50,000 0 0
Celldex Therapeutics Inc EQUITIES 15117B202   339,300 10,000 SH   SOLE   10,000 0 0
Cerus Corp EQUITIES 157085101   2,849,332 1,158,265 SH   SOLE   1,158,265 0 0
Clene Inc EQUITIES 185634102   219,975 250,000 SH   SOLE   250,000 0 0
Cogent Biosciences Inc EQUITIES 19240Q201   7,340,800 620,000 SH   SOLE   620,000 0 0
Compugen Ltd EQUITIES M25722105   376,414 330,188 SH   SOLE   330,188 0 0
Cue Biopharma Inc EQUITIES 22978P106   1,472,417 403,402 SH   SOLE   403,402 0 0
CymaBay Therapeutics Inc EQUITIES 23257D103   1,752,000 160,000 SH   SOLE   160,000 0 0
Eliem Therapeutics Inc EQUITIES 28658R106   1,383,449 494,089 SH   SOLE   494,089 0 0
Eloxx Pharmaceuticals Inc EQUITIES 29014R202   210,352 54,075 SH   SOLE   54,075 0 0
Evogene Ltd EQUITIES M4119S104   107,000 100,000 SH   SOLE   100,000 0 0
FibroGen Inc LONG OPTION CALLS 31572Q808   271,000 100,000 SH Call SOLE   100,000 0 0
Fresh Tracks Therapeutics Inc EQUITIES 10802T204   7,013 10,000 SH   SOLE   10,000 0 0
Gilead Sciences Inc EQUITIES 375558103   4,658,727 60,448 SH   SOLE   60,448 0 0
Glaukos Corp EQUITIES 377322102   71,210 1,000 SH   SOLE   1,000 0 0
Immatics Nv EQUITIES N44445109   354,451 30,715 SH   SOLE   30,715 0 0
ImmunoGen Inc EQUITIES 45253H101   26,795,400 1,420,000 SH   SOLE   1,420,000 0 0
Incyte Corp EQUITIES 45337C102   2,123,348 34,110 SH   SOLE   34,110 0 0
Insmed Inc EQUITIES 457669307   3,048,190 144,464 SH   SOLE   144,464 0 0
Intellia Therapeutics Inc EQUITIES 45826J105   2,073,989 50,858 SH   SOLE   50,858 0 0
Intra-Cellular Therapies Inc EQUITIES 46116X101   12,583,140 198,723 SH   SOLE   198,723 0 0
Jasper Therapeutics Inc EQUITIES 471871103   685,000 500,000 SH   SOLE   500,000 0 0
KalVista Pharmaceuticals Inc EQUITIES 483497103   6,484,572 720,508 SH   SOLE   720,508 0 0
Karyopharm Therapeutics Inc EQUITIES 48576U106   928,983 518,985 SH   SOLE   518,985 0 0
Krystal Biotech Inc EQUITIES 501147102   13,963,673 118,941 SH   SOLE   118,941 0 0
MacroGenics Inc EQUITIES 556099109   6,503,861 1,215,675 SH   SOLE   1,215,675 0 0
Mersana Therapeutics Inc LONG OPTION CALLS 59045L106   3,619,000 1,100,000 SH Call SOLE   1,100,000 0 0
Mersana Therapeutics Inc EQUITIES 59045L106   3,290,000 1,000,000 SH   SOLE   1,000,000 0 0
Merus NV EQUITIES N5749R100   15,515,084 589,255 SH   SOLE   589,255 0 0
Mirati Therapeutics Inc LONG OPTION CALLS 60468T105   5,419,500 150,000 SH Call SOLE   150,000 0 0
Mirati Therapeutics Inc EQUITIES 60468T105   3,295,526 91,213 SH   SOLE   91,213 0 0
Mirum Pharmaceuticals Inc EQUITIES 604749101   2,751,921 106,375 SH   SOLE   106,375 0 0
Monte Rosa Therapeutics Inc EQUITIES 61225M102   213,419 31,156 SH   SOLE   31,156 0 0
MoonLake Immunotherapeutics EQUITIES 61559X104   10,200,000 200,000 SH   SOLE   200,000 0 0
Morphic Holding Inc EQUITIES 61775R105   14,464,875 252,309 SH   SOLE   252,309 0 0
Nuvalent Inc EQUITIES 670703107   4,852,375 115,067 SH   SOLE   115,067 0 0
Olema Pharmaceuticals Inc EQUITIES 68062P106   3,525,908 390,466 SH   SOLE   390,466 0 0
Oric Pharmaceuticals Inc EQUITIES 68622P109   11,258,379 1,450,822 SH   SOLE   1,450,822 0 0
Pharvaris NV EQUITIES N69605108   3,028,000 200,000 SH   SOLE   200,000 0 0
Phathom Pharmaceuticals Inc EQUITIES 71722W107   2,864,000 200,000 SH   SOLE   200,000 0 0
Pieris Pharmaceuticals Inc EQUITIES 720795103   159,101 961,338 SH   SOLE   961,338 0 0
Pliant Therapeutics Inc EQUITIES 729139105   1,943,678 107,267 SH   SOLE   107,267 0 0
Point Biopharma Global Inc EQUITIES 730541109   848,922 93,700 SH   SOLE   93,700 0 0
Poseida Therapeutics Inc EQUITIES 73730P108   5,184,868 2,945,948 SH   SOLE   2,945,948 0 0
Praxis Precision Medicines Inc EQUITIES 74006W108   3,997,586 3,476,162 SH   SOLE   3,476,162 0 0
Protagonist Therapeutics Inc EQUITIES 74366E102   690,500 25,000 SH   SOLE   25,000 0 0
Prothena Corporation PLC EQUITIES G72800108   3,394,950 49,721 SH   SOLE   49,721 0 0
Reata Pharmaceuticals Inc EQUITIES 75615P103   1,274,500 12,500 SH   SOLE   12,500 0 0
Rezolute Inc EQUITIES 76200L309   989,097 499,544 SH   SOLE   499,544 0 0
Rhythm Pharmaceuticals Inc EQUITIES 76243J105   1,915,610 116,168 SH   SOLE   116,168 0 0
Rocket Pharmaceuticals Inc WARRANTS 77313F114   19,917 104,828 SH   SOLE   104,828 0 0
Sarepta Therapeutics Inc EQUITIES 803607100   3,419,567 29,860 SH   SOLE   29,860 0 0
Schrodinger Inc EQUITIES 80810D103   14,285,556 286,169 SH   SOLE   286,169 0 0
Syndax Pharmaceuticals Inc EQUITIES 87164F105   418,600 20,000 SH   SOLE   20,000 0 0
Tela Bio Inc EQUITIES 872381108   4,218,537 416,440 SH   SOLE   416,440 0 0
Terns Pharmaceuticals Inc EQUITIES 880881107   5,247,095 599,668 SH   SOLE   599,668 0 0
Trevi Therapeutics Inc EQUITIES 89532M101   2,117,358 885,924 SH   SOLE   885,924 0 0
United Therapeutics Corp EQUITIES 91307C102   6,628,902 30,029 SH   SOLE   30,029 0 0
Ventyx Biosciences Inc EQUITIES 92332V107   820,000 25,000 SH   SOLE   25,000 0 0
Veracyte Inc EQUITIES 92337F107   5,844,117 229,451 SH   SOLE   229,451 0 0
Vertex Pharmaceuticals Inc EQUITIES 92532F100   4,636,414 13,175 SH   SOLE   13,175 0 0
Viewray Inc EQUITIES 92672L107   35,220 100,000 SH   SOLE   100,000 0 0
Viking Therapeutics Inc EQUITIES 92686J106   4,191,825 258,595 SH   SOLE   258,595 0 0
Viridian Therapeutics Inc EQUITIES 92790C104   1,070,550 45,000 SH   SOLE   45,000 0 0
Voyager Therapeutics Inc EQUITIES 92915B106   1,145,000 100,000 SH   SOLE   100,000 0 0
Xenon Pharmaceuticals Inc EQUITIES 98420N105   3,840,606 99,756 SH   SOLE   99,756 0 0
Zura Bio Ltd EQUITIES G9TY5A101   1,312,000 160,000 SH   SOLE   160,000 0 0