The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACELYRIN INC COM 00445A100   60,995,103 2,918,426 SH   SOLE   2,918,426 0 0
ACELYRIN INC COM 00445A100   2,090,000 100,000 SH Call SOLE   100,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   2,075,690 200,163 SH   SOLE   200,163 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   8,257,631 796,300 SH Put SOLE   796,300 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   3,150,286 654,945 SH   SOLE   654,945 0 0
ALLAKOS INC COM 01671P100   3,366,321 772,092 SH   SOLE   772,092 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103   340,523 156,203 SH   SOLE   156,203 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   12,189,180 133,800 SH   SOLE   133,800 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   12,116,300 133,000 SH Put SOLE   133,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   5,686,800 280,000 SH   SOLE   280,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,062,000 200,000 SH Call SOLE   200,000 0 0
ARDELYX INC COM 039697107   945,216 278,825 SH   SOLE   278,825 0 0
ARGENX SE SPONSORED ADR 04016X101   14,809,740 38,000 SH Call SOLE   38,000 0 0
ARGENX SE SPONSORED ADR 04016X101   51,483,333 132,100 SH Put SOLE   132,100 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   4,635,800 130,000 SH   SOLE   130,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   186,532 2,090 SH   SOLE   2,090 0 0
ASLAN PHARMACEUTICALS LTD SPON ADS NEW 04522R200   29,813 164,088 SH   SOLE   164,088 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   17,892,500 250,000 SH Call SOLE   250,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   4,826,318 579,390 SH   SOLE   579,390 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   619,006 260,087 SH   SOLE   260,087 0 0
AVROBIO INC COM 05455M100   127,453 134,146 SH   SOLE   134,146 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   5,181,504 203,037 SH   SOLE   203,037 0 0
BIOHAVEN LTD COM G1110E107   10,223,814 427,417 SH   SOLE   427,417 0 0
BIOHAVEN LTD COM G1110E107   5,382,000 225,000 SH Call SOLE   225,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   8,668,000 100,000 SH Put SOLE   100,000 0 0
BIOMEA FUSION INC COM 09077A106   6,055,457 275,875 SH   SOLE   275,875 0 0
BIOMEA FUSION INC COM 09077A106   20,562,760 936,800 SH Call SOLE   936,800 0 0
BIOMEA FUSION INC COM 09077A106   6,293,065 286,700 SH Put SOLE   286,700 0 0
BIOVIE INC CL A NEW 09074F207   1,933,276 448,556 SH   SOLE   448,556 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   2,752,770 545,103 SH   SOLE   545,103 0 0
BLUEBIRD BIO INC COM 09609G100   1,357,545 412,628 SH   SOLE   412,628 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201   391,266 189,935 SH   SOLE   189,935 0 0
BRIDGEBIO PHARMA INC COM 10806X102   7,390,599 429,686 SH   SOLE   429,686 0 0
BRIDGEBIO PHARMA INC COM 10806X102   21,152,560 1,229,800 SH Call SOLE   1,229,800 0 0
BRIDGEBIO PHARMA INC COM 10806X102   2,580,000 150,000 SH Put SOLE   150,000 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   279,543 213,392 SH   SOLE   213,392 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   130,394 283,464 SH   SOLE   283,464 0 0
COGENT BIOSCIENCES INC COM 19240Q201   743,150 62,766 SH   SOLE   62,766 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101   243,645 219,501 SH   SOLE   219,501 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   1,507,318 192,260 SH   SOLE   192,260 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   8,559,501 475,000 SH   SOLE   475,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   11,228,000 200,000 SH Call SOLE   200,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   11,228,000 200,000 SH Put SOLE   200,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   2,457,101 174,510 SH   SOLE   174,510 0 0
DICE THERAPEUTICS INC COM 23345J104   2,025,656 43,600 SH Put SOLE   43,600 0 0
DISC MEDICINE INC COM 254604101   10,657,376 240,031 SH   SOLE   240,031 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   303,908 221,830 SH   SOLE   221,830 0 0
ELEVATION ONCOLOGY INC COM 28623U101   1,747,225 1,149,490 SH   SOLE   1,149,490 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   2,370,791 1,705,605 SH   SOLE   1,705,605 0 0
FIBROGEN INC COM 31572Q808   616,735 228,420 SH   SOLE   228,420 0 0
FIBROGEN INC COM 31572Q808   1,080,000 400,000 SH Call SOLE   400,000 0 0
FIBROGEN INC COM 31572Q808   1,024,110 379,300 SH Put SOLE   379,300 0 0
FINCH THERAPEUTICS GROUP INC COM NEW 31773D200   67,533 7,917 SH   SOLE   7,917 0 0
FOGHORN THERAPEUTICS INC COM 344174107   105,601 15,000 SH   SOLE   15,000 0 0
HOOKIPA PHARMA INC COM 43906K100   528,000 600,000 SH   SOLE   600,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   11,535,987 490,893 SH   SOLE   490,893 0 0
IMMATICS N.V SHS N44445109   565,817 49,031 SH   SOLE   49,031 0 0
IMMUNIC INC COM 4525EP101   1,631,500 650,000 SH   SOLE   650,000 0 0
IMMUNOGEN INC COM 45253H101   8,448,099 447,700 SH   SOLE   447,700 0 0
IMMUNOGEN INC COM 45253H101   6,604,500 350,000 SH Call SOLE   350,000 0 0
IMMUNOVANT INC COM 45258J102   6,188,014 326,200 SH Call SOLE   326,200 0 0
IMMUNOVANT INC COM 45258J102   1,441,720 76,000 SH Put SOLE   76,000 0 0
INSMED INC COM PAR $.01 457669307   10,233,500 485,000 SH   SOLE   485,000 0 0
INSMED INC COM PAR $.01 457669307   4,220,000 200,000 SH Call SOLE   200,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108   1,771,813 160,200 SH   SOLE   160,200 0 0
JASPER THERAPEUTICS INC COM 471871103   1,541,370 1,125,087 SH   SOLE   1,125,087 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   1,260,000 140,000 SH   SOLE   140,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   716,000 400,000 SH   SOLE   400,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   2,061,910 841,596 SH   SOLE   841,596 0 0
KODIAK SCIENCES INC COM 50015M109   431,436 62,527 SH   SOLE   62,527 0 0
KRYSTAL BIOTECH INC COM 501147102   1,209,220 10,300 SH Put SOLE   10,300 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   1,725,751 25,000 SH   SOLE   25,000 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   4,749,264 68,800 SH Call SOLE   68,800 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   3,701,216 504,253 SH   SOLE   504,253 0 0
LYRA THERAPEUTICS INC COM 55234L105   4,022,153 978,626 SH   SOLE   978,626 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   17,325 75 SH   SOLE   75 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   6,645,582 611,932 SH   SOLE   611,932 0 0
MERCK & CO INC COM 58933Y105   11,538,999 100,000 SH   SOLE   100,000 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   300,235 891,676 SH   SOLE   891,676 0 0
MERSANA THERAPEUTICS INC COM 59045L106   164,501 50,000 SH   SOLE   50,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106   363,874 110,600 SH Call SOLE   110,600 0 0
MERUS N V COM N5749R100   1,662,081 63,125 SH   SOLE   63,125 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   1,312,186 460,416 SH   SOLE   460,416 0 0
NOVAVAX INC COM NEW 670002401   2,972,000 400,000 SH Call SOLE   400,000 0 0
NOVAVAX INC COM NEW 670002401   2,972,000 400,000 SH Put SOLE   400,000 0 0
NUVALENT INC COM 670703107   11,501,952 272,752 SH   SOLE   272,752 0 0
NUVALENT INC COM 670703107   185,548 4,400 SH Call SOLE   4,400 0 0
OCULAR THERAPEUTIX INC COM 67576A100   516,000 100,000 SH   SOLE   100,000 0 0
PHAXIAM THERAPEUTICS S A SPONSORED ADR 29604W108   2,257 3,019 SH   SOLE   3,019 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   260,783 28,784 SH   SOLE   28,784 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109   765,653 472,625 SH   SOLE   472,625 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   966,700 35,000 SH   SOLE   35,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   5,524,000 200,000 SH Call SOLE   200,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   5,838,868 211,400 SH Put SOLE   211,400 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107   450,907 188,664 SH   SOLE   188,664 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   557,925 5,472 SH   SOLE   5,472 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   11,215,600 110,000 SH Call SOLE   110,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402   161,109 65,491 SH   SOLE   65,491 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   1,022,173 155,819 SH   SOLE   155,819 0 0
REPLIMUNE GROUP INC COM 76029N106   5,301,126 228,300 SH Call SOLE   228,300 0 0
REPLIMUNE GROUP INC COM 76029N106   8,085,204 348,200 SH Put SOLE   348,200 0 0
ROIVANT SCIENCES LTD SHS G76279101   2,267,999 225,000 SH   SOLE   225,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100   2,530,892 22,100 SH Call SOLE   22,100 0 0
SAREPTA THERAPEUTICS INC COM 803607100   13,982,892 122,100 SH Put SOLE   122,100 0 0
SCPHARMACEUTICALS INC COM 810648105   1,528,500 150,000 SH   SOLE   150,000 0 0
STOKE THERAPEUTICS INC COM 86150R107   748,245 70,390 SH   SOLE   70,390 0 0
STOKE THERAPEUTICS INC COM 86150R107   2,287,576 215,200 SH Call SOLE   215,200 0 0
SYNLOGIC INC COM 87166L100   131,905 306,757 SH   SOLE   306,757 0 0
TERNS PHARMACEUTICALS INC COM 880881107   2,760,451 315,480 SH   SOLE   315,480 0 0
TERNS PHARMACEUTICALS INC COM 880881107   1,750,000 200,000 SH Call SOLE   200,000 0 0
TG THERAPEUTICS INC COM 88322Q108   20,520,324 826,100 SH Call SOLE   826,100 0 0
TG THERAPEUTICS INC COM 88322Q108   20,520,324 826,100 SH Put SOLE   826,100 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209   804,769 2,765,530 SH   SOLE   2,765,530 0 0
TYRA BIOSCIENCES INC COM 90240B106   820,336 48,170 SH   SOLE   48,170 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   5,612,084 121,658 SH   SOLE   121,658 0 0
UNIQURE NV SHS N90064101   1,769,424 154,400 SH Call SOLE   154,400 0 0
VAXCYTE INC COM 92243G108   6,991,600 140,000 SH   SOLE   140,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   12,270,480 374,100 SH Put SOLE   374,100 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   219,207 313,677 SH   SOLE   313,677 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   3,435,000 300,000 SH   SOLE   300,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103   677,318 349,133 SH   SOLE   349,133 0 0
XENON PHARMACEUTICALS INC COM 98420N105   5,216,212 135,486 SH   SOLE   135,486 0 0