The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   88,580 885 SH   SOLE   885 0 0
908 DEVICES INC COM 65443P102   6,005,566 875,447 SH   SOLE   846,818 0 28,629
ABSCI CORPORATION COM 00091E109   1,986,135 1,306,668 SH   SOLE   1,306,668 0 0
AC IMMUNE SA SHS H00263105   3,907,875 1,322,462 SH   SOLE   1,322,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   2,457,403 366,230 SH   SOLE   366,230 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101   130,560 267 SH   SOLE   267 0 0
ALECTOR INC COM 014442107   1,091,951 181,689 SH   SOLE   181,689 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   71,981,643 863,607 SH   SOLE   786,375 0 77,232
ALLAKOS INC COM 01671P100   2,768,700 635,023 SH   SOLE   635,023 0 0
ALLISON TRANSMISSION HLDGS I COM 01973R101   188,520 3,339 SH   SOLE   3,339 0 0
ALLY FINL INC COM 02005N100   17,379,855 643,460 SH   SOLE   643,460 0 0
ALPHA TEKNOVA INC COM 02080L102   825,505 309,178 SH   SOLE   309,178 0 0
ALPHABET INC CAP STK CL A 02079K305   70,321,715 587,483 SH   SOLE   387,335 0 200,148
ALPHABET INC CAP STK CL C 02079K107   72,018,885 595,345 SH   SOLE   595,345 0 0
ALTIMMUNE INC COM NEW 02155H200   335,636 95,081 SH   SOLE   95,081 0 0
AMAZON COM INC COM 023135106   951,367 7,298 SH   SOLE   7,298 0 0
ANALOG DEVICES INC COM 032654105   1,429,321 7,337 SH   SOLE   7,337 0 0
APPLIED MATLS INC COM 038222105   2,172,292 15,029 SH   SOLE   15,029 0 0
APTIV PLC SHS G6095L109   123,427 1,209 SH   SOLE   1,209 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,724,350 232,612 SH   SOLE   232,612 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   3,465,011 97,168 SH   SOLE   97,168 0 0
AT&T INC COM 00206R102   88,475 5,547 SH   SOLE   5,547 0 0
AUTOLIV INC COM 052800109   116,335 1,368 SH   SOLE   1,368 0 0
BALL CORP COM 058498106   216,425 3,718 SH   SOLE   3,718 0 0
BAXTER INTL INC COM 071813109   67,800,980 1,488,169 SH   SOLE   1,323,867 0 164,302
BEST BUY INC COM 086516101   94,980 1,159 SH   SOLE   1,159 0 0
BIO RAD LABS INC CL A 090572207   3,274,080 8,636 SH   SOLE   8,636 0 0
BIOGEN INC COM 09062X103   6,848,933 24,044 SH   SOLE   24,044 0 0
BIONTECH SE SPONSORED ADS 09075V102   7,105,895 65,838 SH   SOLE   65,838 0 0
BLACK KNIGHT INC COM 09215C105   1,225,182 20,512 SH   SOLE   20,512 0 0
BLOCK INC CL A 852234103   17,188,507 258,202 SH   SOLE   258,202 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   3,550,007 56,171 SH   SOLE   56,171 0 0
BOOKING HOLDINGS INC COM 09857L108   25,728,744 9,528 SH   SOLE   9,528 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305   94,520 2,087 SH   SOLE   2,087 0 0
CAMECO CORP COM 13321L108   37,763,132 1,205,231 SH   SOLE   1,205,231 0 0
CAPRI HOLDINGS LIMITED SHS G1890L107   82,368 2,295 SH   SOLE   2,295 0 0
CARLISLE COS INC COM 142339100   72,921,987 284,263 SH   SOLE   250,366 0 33,897
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   1,062,359 171,625 SH   SOLE   171,625 0 0
CENTOGENE N V COM N1976T109   3,565,725 2,377,150 SH   SOLE   2,377,150 0 0
CF INDS HLDGS INC COM 125269100   19,993 288 SH   SOLE   288 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108   149,152 406 SH   SOLE   406 0 0
CIENA CORP COM NEW 171779309   2,044,746 48,123 SH   SOLE   48,123 0 0
CISCO SYS INC COM 17275R102   551,134 10,652 SH   SOLE   10,652 0 0
COGENT BIOSCIENCES INC COM 19240Q201   5,648,627 477,080 SH   SOLE   452,247 0 24,833
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102   91,588 1,403 SH   SOLE   1,403 0 0
CORE LABORATORIES INC COM 21867A105   90,187 3,879 SH   SOLE   3,879 0 0
CROWN HLDGS INC COM 228368106   282,414 3,251 SH   SOLE   3,251 0 0
CUREVAC N V COM N2451R105   2,356,316 226,134 SH   SOLE   226,134 0 0
DENALI THERAPEUTICS INC COM 24823R105   1,633,113 55,341 SH   SOLE   55,341 0 0
DINGDONG CAYMAN LTD ADS 25445D101   29,807,188 9,646,339 SH   SOLE   9,506,070 0 140,269
DOORDASH INC CL A 25809K105   16,189,577 211,850 SH   SOLE   211,850 0 0
ERICSSON ADR B SEK 10 294821608   1,761,304 323,175 SH   SOLE   323,175 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   4,822,791 3,469,634 SH   SOLE   3,199,318 0 270,316
EXSCIENTIA PLC ADS 30223G102   23,618,621 3,989,632 SH   SOLE   3,953,475 0 36,157
FOX CORP CL A COM 35137L105   46,444 1,366 SH   SOLE   1,366 0 0
FREEPORT-MCMORAN INC CL B 35671D857   7,939,120 198,478 SH   SOLE   198,478 0 0
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108   1,238,346 199,091 SH   SOLE   199,091 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107   23,713,387 291,893 SH   SOLE   194,369 0 97,524
GILEAD SCIENCES INC COM 375558103   53,602,570 695,505 SH   SOLE   474,884 0 220,621
GOSSAMER BIO INC COM 38341P102   2,835,804 2,363,170 SH   SOLE   2,363,170 0 0
H WORLD GROUP LTD SPONSORED ADS 44332N106   14,160,595 365,152 SH   SOLE   365,152 0 0
HANESBRANDS INC COM 410345102   87,726 19,323 SH   SOLE   19,323 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   46,275 1,315 SH   SOLE   1,315 0 0
HELLO GROUP INC ADS 423403104   45,388 4,723 SH   SOLE   4,723 0 0
HERBALIFE LTD COM SHS G4412G101   88,973 6,720 SH   SOLE   6,720 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   2,184,624 182,052 SH   SOLE   182,052 0 0
ICOSAVAX INC COM 45114M109   23,190,026 2,335,350 SH   SOLE   2,180,820 0 154,530
IDEAYA BIOSCIENCES INC COM 45166A102   19,144,745 814,670 SH   SOLE   709,735 0 104,935
IMMATICS N.V SHS N44445109   3,095,155 268,211 SH   SOLE   268,211 0 0
IMMUNOVANT INC COM 45258J102   6,238,133 328,842 SH   SOLE   328,842 0 0
INHIBRX INC COM 45720L107   5,945,775 229,036 SH   SOLE   229,036 0 0
INTEL CORP COM 458140100   255,080 7,628 SH   SOLE   7,628 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104   166,542,528 1,472,785 SH   SOLE   1,117,790 0 354,995
IRIS ENERGY LTD ORDINARY SHARES Q4982L109   12,270,521 2,633,159 SH   SOLE   2,268,031 0 365,128
JACKSON FINANCIAL INC COM CL A 46817M107   77,596 2,535 SH   SOLE   2,535 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   86,407 697 SH   SOLE   697 0 0
JD.COM INC SPON ADR CL A 47215P106   16,560,354 485,214 SH   SOLE   485,214 0 0
JOHNSON & JOHNSON COM 478160104   7,058,931 42,647 SH   SOLE   42,647 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   895,000 500,000 SH   SOLE   500,000 0 0
KOHLS CORP COM 500255104   90,102 3,909 SH   SOLE   3,909 0 0
KYNDRYL HLDGS INC COMMON STOCK 50155Q100   3,200 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108   8,452,323 13,148 SH   SOLE   13,148 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854   1,151,784 15,300 SH   SOLE   15,300 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102   25,952 18,148 SH   SOLE   18,148 0 0
MATCH GROUP INC NEW COM 57667L107   4,512,518 107,826 SH   SOLE   107,826 0 0
MERUS N V COM N5749R100   3,955,767 150,238 SH   SOLE   150,238 0 0
META PLATFORMS INC CL A 30303M102   65,703,497 228,948 SH   SOLE   228,948 0 0
METALS ACQUISITION LIMITED ORD SHS G60409110   20,937,850 2,032,801 SH   SOLE   1,516,526 0 516,275
MICROCHIP TECHNOLOGY INC. COM 595017104   295,345,171 3,296,631 SH   SOLE   2,792,896 0 503,735
MICRON TECHNOLOGY INC COM 595112103   113,096,149 1,792,048 SH   SOLE   1,424,033 0 368,015
MICROSOFT CORP COM 594918104   7,002,865 20,564 SH   SOLE   20,564 0 0
MOBILEYE GLOBAL INC COMMON CLASS A 60741F104   12,483,465 324,921 SH   SOLE   213,710 0 111,211
MODERNA INC COM 60770K107   4,632,309 38,126 SH   SOLE   38,126 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109   4,521,388 1,116,392 SH   SOLE   1,085,273 0 31,119
NETFLIX INC COM 64110L106   6,484,894 14,722 SH   SOLE   14,722 0 0
NEW YORK CMNTY BANCORP INC COM 649445103   96,169 8,556 SH   SOLE   8,556 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102   36,639,736 2,602,254 SH   SOLE   2,602,254 0 0
NVIDIA CORPORATION COM 67066G104   274,963 650 SH   SOLE   650 0 0
NXP SEMICONDUCTORS N V COM N6596X109   66,219,506 323,527 SH   SOLE   275,331 0 48,196
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105   4,974,676 888,335 SH   SOLE   861,534 0 26,801
ONEMAIN HLDGS INC COM 68268W103   90,264 2,066 SH   SOLE   2,066 0 0
ORACLE CORP COM 68389X105   2,158,149 18,122 SH   SOLE   18,122 0 0
ORCHARD THERAPEUTICS PLC SPON ADS NEW 68570P200   1,294,487 248,462 SH   SOLE   248,462 0 0
PAYPAL HLDGS INC COM 70450Y103   1,429,156 21,417 SH   SOLE   21,417 0 0
PDD HOLDINGS INC SPONSORED ADS 722304102   75,226,118 1,088,026 SH   SOLE   880,985 0 207,041
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408   40,534,693 2,930,925 SH   SOLE   1,926,583 0 1,004,342
PLANET FITNESS INC CL A 72703H101   12,640,684 187,436 SH   SOLE   187,436 0 0
PROTHENA CORP PLC SHS G72800108   2,834,166 41,508 SH   SOLE   41,508 0 0
QUANTERIX CORP COM 74766Q101   16,145,823 716,001 SH   SOLE   670,028 0 45,973
RALPH LAUREN CORP CL A 751212101   93,092 755 SH   SOLE   755 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104   20,252,276 2,711,148 SH   SOLE   2,665,854 0 45,294
RH COM 74967X103   64,393,646 195,375 SH   SOLE   164,912 0 30,463
ROIVANT SCIENCES LTD SHS G76279101   7,646,436 758,575 SH   SOLE   758,575 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203   1,106,000 10,000 SH   SOLE   10,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   4,322,690 91,933 SH   SOLE   91,933 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,149,094 10,034 SH   SOLE   10,034 0 0
SCHLUMBERGER LTD COM STK 806857108   105,289,948 2,143,525 SH   SOLE   1,825,442 0 318,083
SCHWAB CHARLES CORP COM 808513105   1,417,000 25,000 SH   SOLE   25,000 0 0
SCORPIO TANKERS INC SHS Y7542C130   51,336,649 1,086,950 SH   SOLE   882,984 0 203,966
SILVERCREST METALS INC COM 828363101   10,229,779 1,745,696 SH   SOLE   1,160,649 0 585,047
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   731,286 881,068 SH   SOLE   881,068 0 0
SKYWORKS SOLUTIONS INC COM 83088M102   1,859,260 16,797 SH   SOLE   16,797 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   623,550 15,000 SH   SOLE   15,000 0 0
SUNCOR ENERGY INC NEW COM 867224107   46,574,938 1,586,039 SH   SOLE   1,091,893 0 494,146
SUZANO S A SPON ADS 86959K105   43,739,966 4,744,031 SH   SOLE   4,744,031 0 0
THE CIGNA GROUP COM 125523100   80,252 286 SH   SOLE   286 0 0
THOR INDS INC COM 885160101   98,015 947 SH   SOLE   947 0 0
TORM PLC SHS CL A G89479102   2,156,618 89,264 SH   SOLE   89,264 0 0
TRANSUNION COM 89400J107   154,015,031 1,966,233 SH   SOLE   1,582,880 0 383,353
TRIP COM GROUP LTD ADS 89677Q107   129,996,965 3,714,199 SH   SOLE   3,175,458 0 538,741
TWILIO INC CL A 90138F102   430,835 6,772 SH   SOLE   6,772 0 0
TYSON FOODS INC CL A 902494103   89,065 1,745 SH   SOLE   1,745 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100   98,133 622 SH   SOLE   622 0 0
VALARIS LIMITED CL A G9460G101   49,182,249 781,539 SH   SOLE   662,805 0 118,734
VEEVA SYS INC CL A COM 922475108   621,268 3,142 SH   SOLE   3,142 0 0
VERA THERAPEUTICS INC CL A 92337R101   3,365,685 209,700 SH   SOLE   209,700 0 0
VITAL ENERGY INC COM 516806205   48,085 1,065 SH   SOLE   1,065 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104   44,141 3,520 SH   SOLE   3,520 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   1,657,405 455,331 SH   SOLE   455,331 0 0
ZAI LAB LTD ADR 98887Q104   3,737,533 134,783 SH   SOLE   134,783 0 0
ZOOMINFO TECHNOLOGIES INC COMMON STOCK 98980F104   372,243 14,661 SH   SOLE   14,661 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105   393,130,028 15,675,041 SH   SOLE   13,254,919 0 2,420,122
ZYMEWORKS INC COM 98985Y108   3,541,009 409,839 SH   SOLE   409,839 0 0