The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108   1,129,200 60,000 SH   SOLE   60,000 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500   989,535 174,714 SH   SOLE   174,714 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   5,921,880 732,000 SH Put SOLE   732,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   4,767,437 589,300 SH Call SOLE   589,300 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   2,428,319 300,163 SH   SOLE   300,163 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   1,035,077 254,945 SH   SOLE   254,945 0 0
AEROVATE THERAPEUTICS INC COM 008064107   3,936,094 195,146 SH   SOLE   195,146 0 0
AKERO THERAPEUTICS INC COM 00973Y108   1,913,000 50,000 SH   SOLE   50,000 0 0
ALTIMMUNE INC COM NEW 02155H200   4,545,784 1,077,200 SH Put SOLE   1,077,200 0 0
ALTIMMUNE INC COM NEW 02155H200   3,792,092 898,600 SH Call SOLE   898,600 0 0
ALTIMMUNE INC COM NEW 02155H200   2,858,206 677,300 SH   SOLE   677,300 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   293,400 10,000 SH   SOLE   10,000 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   4,401,000 150,000 SH Call SOLE   150,000 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103   462,360 156,203 SH   SOLE   156,203 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   6,595,999 100,000 SH   SOLE   100,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,195,200 230,000 SH   SOLE   230,000 0 0
ARDELYX INC COM 039697107   2,772,572 578,825 SH   SOLE   578,825 0 0
ARK ETF TR INNOVATION ETF 00214Q104   182,297 4,519 SH   SOLE   4,519 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302   1,397,112 46,462 SH   SOLE   46,462 0 0
ASLAN PHARMACEUTICALS LTD SPON ADS NEW 04522R200   475,856 164,088 SH   SOLE   164,088 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   11,562,887 869,390 SH   SOLE   869,390 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   478,559 260,087 SH   SOLE   260,087 0 0
AXSOME THERAPEUTICS INC COM 05464T104   9,252,000 150,000 SH Call SOLE   150,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104   9,252,000 150,000 SH Put SOLE   150,000 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404   147,873 448,101 SH   SOLE   448,101 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   6,374,405 885,334 SH   SOLE   885,334 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   4,254,000 200,000 SH Call SOLE   200,000 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   4,405,273 207,112 SH   SOLE   207,112 0 0
BIOGEN INC COM 09062X103   267,465 962 SH   SOLE   962 0 0
BIOHAVEN LTD COM G1110E107   617,432 45,200 SH Call SOLE   45,200 0 0
BIOHAVEN LTD COM G1110E107   5,495,774 402,326 SH   SOLE   402,326 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   4,862,000 50,000 SH   SOLE   50,000 0 0
BIOMEA FUSION INC COM 09077A106   9,023,910 291,000 SH Call SOLE   291,000 0 0
BIOMEA FUSION INC COM 09077A106   1,240,400 40,000 SH Put SOLE   40,000 0 0
BIOMEA FUSION INC COM 09077A106   6,542,334 210,975 SH   SOLE   210,975 0 0
BIOVIE INC CL A NEW 09074F207   2,816,332 348,556 SH   SOLE   348,556 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105   1,328,592 71,200 SH Call SOLE   71,200 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105   2,482,041 133,014 SH   SOLE   133,014 0 0
BLUEBIRD BIO INC COM 09609G100   1,312,157 412,628 SH   SOLE   412,628 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201   626,786 189,935 SH   SOLE   189,935 0 0
BRIDGEBIO PHARMA INC COM 10806X102   9,112,368 549,600 SH Call SOLE   549,600 0 0
BRIDGEBIO PHARMA INC COM 10806X102   9,859,894 594,686 SH   SOLE   594,686 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   3,815,932 106,057 SH   SOLE   106,057 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   3,957,800 110,000 SH Put SOLE   110,000 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104   342,091 236,709 SH   SOLE   236,709 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   6,562,191 283,464 SH   SOLE   283,464 0 0
COGENT BIOSCIENCES INC COM 19240Q201   677,246 62,766 SH   SOLE   62,766 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101   219,479 219,501 SH   SOLE   219,501 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   1,397,730 192,260 SH   SOLE   192,260 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603   10,999 275,000 SH   SOLE   275,000 0 0
CYTOKINETICS INC COM NEW 23282W605   1,958,886 55,666 SH   SOLE   55,666 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   2,696,179 174,510 SH   SOLE   174,510 0 0
DELCATH SYS INC COM NEW 24661P807   1,078,601 360,569 SH   SOLE   360,569 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   523,518 221,830 SH   SOLE   221,830 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108   252,111 248,426 SH   SOLE   248,426 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   2,155,411 1,355,605 SH   SOLE   1,355,605 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101   93,359 237,553 SH   SOLE   237,553 0 0
GENFIT S A ADS 372279109   131,511 32,786 SH   SOLE   32,786 0 0
GOSSAMER BIO INC COM 38341P102   7,686 6,100 SH   SOLE   6,100 0 0
IMMATICS N.V SHS N44445109   526,266 179,552 SH   SOLE   179,552 0 0
IMMUNIC INC COM 4525EP101   968,500 650,000 SH   SOLE   650,000 0 0
IMMUNOGEN INC COM 45253H101   409,344 106,600 SH Call SOLE   106,600 0 0
IMMUNOVANT INC COM 45258J102   2,486,253 160,300 SH Call SOLE   160,300 0 0
IMMUNOVANT INC COM 45258J102   12,010,913 774,398 SH   SOLE   774,398 0 0
INSMED INC COM PAR $.01 457669307   8,269,250 485,000 SH   SOLE   485,000 0 0
INSMED INC COM PAR $.01 457669307   3,410,000 200,000 SH Call SOLE   200,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108   1,144,236 85,200 SH   SOLE   85,200 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   20,577,000 380,000 SH Call SOLE   380,000 0 0
INVENTIVA SA ADS 46124U107   999,202 292,599 SH   SOLE   292,599 0 0
IVERIC BIO INC COM 46583P102   5,194,967 213,521 SH   SOLE   213,521 0 0
JASPER THERAPEUTICS INC COM 471871103   2,038,579 1,126,287 SH   SOLE   1,126,287 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   1,100,400 140,000 SH   SOLE   140,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   1,167,000 300,000 SH   SOLE   300,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   2,634,195 841,596 SH   SOLE   841,596 0 0
KODIAK SCIENCES INC COM 50015M109   1,007,668 162,527 SH   SOLE   162,527 0 0
KRYSTAL BIOTECH INC COM 501147102   824,618 10,300 SH Put SOLE   10,300 0 0
LYRA THERAPEUTICS INC COM 55234L105   711,427 343,685 SH   SOLE   343,685 0 0
MACROGENICS INC COM 556099109   1,792,500 250,000 SH   SOLE   250,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   18,170 75 SH   SOLE   75 0 0
MERCK & CO INC COM 58933Y105   10,639,000 100,000 SH   SOLE   100,000 0 0
MERUS N V COM N5749R100   3,839,161 208,650 SH   SOLE   208,650 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   1,814,039 460,416 SH   SOLE   460,416 0 0
MIRATI THERAPEUTICS INC COM 60468T105   1,230,658 33,100 SH   SOLE   33,100 0 0
MORPHIC HLDG INC COM 61775R105   1,726,660 45,873 SH   SOLE   45,873 0 0
MORPHIC HLDG INC COM 61775R105   8,032,376 213,400 SH Call SOLE   213,400 0 0
OCULAR THERAPEUTIX INC COM 67576A100   1,054,000 200,000 SH   SOLE   200,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   1,014,639 139,565 SH   SOLE   139,565 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   13,514,378 125,926 SH   SOLE   125,926 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109   1,006,691 472,625 SH   SOLE   472,625 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   4,862,200 211,400 SH Put SOLE   211,400 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   4,862,200 211,400 SH Call SOLE   211,400 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107   584,859 188,664 SH   SOLE   188,664 0 0
PTC THERAPEUTICS INC COM 69366J200   474,712 9,800 SH Call SOLE   9,800 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   9,092,000 100,000 SH Call SOLE   100,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   7,324,879 80,564 SH   SOLE   80,564 0 0
RELMADA THERAPEUTICS INC COM 75955J402   148,010 65,491 SH   SOLE   65,491 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   931,798 155,819 SH   SOLE   155,819 0 0
ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114   59,985 367,112 SH   SOLE   367,112 0 0
ROIVANT SCIENCES LTD SHS G76279101   4,243,500 575,000 SH   SOLE   575,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   747,098 17,805 SH   SOLE   17,805 0 0
SAREPTA THERAPEUTICS INC COM 803607100   28,310,282 205,400 SH Call SOLE   205,400 0 0
SAREPTA THERAPEUTICS INC COM 803607100   37,393,279 271,300 SH Put SOLE   271,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,147,297 8,324 SH   SOLE   8,324 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107   95,037 136,059 SH   SOLE   136,059 0 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209   3,556,137 27,469 SH   SOLE   27,469 0 0
SPDR SER TR S&P BIOTECH 78464A870   7,621,000 100,000 SH Put SOLE   100,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108   132,735 176,980 SH   SOLE   176,980 0 0
SYNLOGIC INC COM 87166L100   193,871 306,757 SH   SOLE   306,757 0 0
TERNS PHARMACEUTICALS INC COM 880881107   8,540,677 721,341 SH   SOLE   721,341 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209   5,226,851 2,765,530 SH   SOLE   2,765,530 0 0
TYRA BIOSCIENCES INC COM 90240B106   774,092 48,170 SH   SOLE   48,170 0 0
VAXCYTE INC COM 92243G108   8,433,000 225,000 SH   SOLE   225,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   2,177,501 65,000 SH   SOLE   65,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   4,591,834 228,677 SH   SOLE   228,677 0 0
VIKING THERAPEUTICS INC COM 92686J106   718,548 43,156 SH   SOLE   43,156 0 0
X4 PHARMACEUTICALS INC COM 98420X103   303,745 349,133 SH   SOLE   349,133 0 0
XENON PHARMACEUTICALS INC COM 98420N105   5,743,793 160,486 SH   SOLE   160,486 0 0