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Clearbridge Investments, LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,151,422 | -186,319 | 1,109,016,775,000 | 57,394,627,000 | $351,909.96 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,337,741 | -148,379 | 1,051,622,148,000 | 44,900,553,000 | $315,070.03 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,486,120 | -414,736 | 1,006,721,595,000 | 1,005,592,141,000 | $288,779.96 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,900,856 | -342,408 | 1,129,454,000 | -66,255,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,243,264 | -909,488 | 1,195,709,000 | -149,005,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,152,752 | -43,978 | 1,344,714,000 | 203,512,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,196,730 | 84,326 | 1,141,202,000 | 213,863,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,112,404 | 129,810 | 927,339,000 | -77,301,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,982,594 | -538,616 | 1,004,640,000 | -181,813,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,521,210 | 1,244,784 | 1,186,453,000 | 175,762,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,276,426 | -194,854 | 1,010,691,000 | -206,034,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,471,280 | 304,248 | 1,216,725,000 | 6,994,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,167,032 | 325,938 | 1,209,731,000 | 295,743,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,841,094 | -283,619 | 913,988,000 | 8,820,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,124,713 | -891,172 | 905,168,000 | 55,377,000 | $219.45 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,015,885 | -161,981 | 849,791,000 | -99,726,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,177,866 | -136,839 | 949,517,000 | -28,123,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,314,705 | -168,447 | 977,640,000 | 69,027,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,483,152 | -62,814 | 908,613,000 | -160,316,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,545,966 | -454,501 | 1,068,929,000 | 49,090,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,000,467 | -390,259 | 1,019,839,000 | -21,721,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,390,726 | -294,943 | 1,041,560,000 | 39,646,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,685,669 | -394,502 | 1,001,914,000 | -74,555,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,080,171 | -838,582 | 1,076,469,000 | 55,979,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,918,753 | -835,865 | 1,020,490,000 | 1,019,532,683 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,754,618 | 105,260 | 957,317 | -636,240,683 | $0.11 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,649,358 | 1,350,349 | 637,198,000 | 651,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,299,009 | 7,299,009 | 636,547,000 | 636,547,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,574,783 | -48,541 | 651,583,000 | 45,605,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,623,324 | -88,934 | 605,978,000 | -364,455,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,712,258 | -80,021 | 970,433,000 | 158,945,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,792,279 | 7,792,279 | 811,488,000 | 811,488,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,861,381 | 7,861,381 | 970,723,000 | 970,723,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,926,054 | 7,926,054 | 935,037,000 | 935,037,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,523,625 | 7,523,625 | 893,807,000 | 893,807,000 | $118.80 |
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