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TWO SIGMA INVESTMENTS, LP
> APLT
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Applied Therapeutics Inc. | APLT | 24,554 | -64,595 | 31,429,000 | -40,880,000 | $1,280.00 |
| 03/31/2023 | Applied Therapeutics Inc. | APLT | 89,149 | -88,624 | 72,309,000 | -62,798,000 | $811.10 |
| 12/31/2022 | Applied Therapeutics Inc. | APLT | 177,773 | -478 | 135,107,000 | 134,938,000 | $760.00 |
| 06/30/2022 | Applied Therapeutics Inc. | APLT | 178,251 | -102,022 | 169,000 | -422,000 | $0.95 |
| 03/31/2022 | Applied Therapeutics Inc. | APLT | 280,273 | 251,842 | 591,000 | 337,000 | $2.11 |
| 12/31/2021 | Applied Therapeutics Inc. | APLT | 28,431 | -703 | 254,000 | -230,000 | $8.93 |
| 09/30/2021 | Applied Therapeutics Inc. | APLT | 29,134 | 18,643 | 484,000 | 266,000 | $16.61 |
| 06/30/2021 | Applied Therapeutics Inc. | APLT | 10,491 | 10,491 | 218,000 | 218,000 | $20.78 |
| 12/31/2020 | Applied Therapeutics Inc. | APLT | 0 | -27,363 | 0 | -568,000 | |
| 09/30/2020 | Applied Therapeutics Inc. | APLT | 27,363 | 27,363 | 568,000 | 568,000 | $20.76 |
| 06/30/2020 | Applied Therapeutics Inc. | APLT | 0 | -7,834 | 0 | -256,000 | |
| 03/31/2020 | Applied Therapeutics Inc. | APLT | 7,834 | 7,834 | 256,000 | 256,000 | $32.68 |
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