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PADCO ADVISORS INC /MD NEW
> GENZ
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2010 | GENZYME CORP | GENZ | 0 | -208,163 | 0 | -10,568,000 | |
| 09/30/2010 | GENZYME CORP | GENZ | 0 | -208,163 | 0 | -10,568,000 | |
| 09/30/2010 | GENZYME CORP | GENZ | 0 | -208,163 | 0 | -10,568,000 | |
| 06/30/2010 | GENZYME CORP | GENZ | 208,163 | -65,822 | 10,568,000 | -2,860,000 | $50.77 |
| 03/31/2010 | GENZYME CORP | GENZ | 359,283 | 85,298 | 18,622,000 | 5,194,000 | $51.83 |
| 12/31/2009 | GENZYME CORP | GENZ | 273,985 | -90,468 | 13,428,000 | -7,247,000 | $49.01 |
| 09/30/2009 | GENZYME CORP | GENZ | 364,453 | 119,328 | 20,675,000 | 7,029,000 | $56.73 |
| 06/30/2009 | GENZYME CORP | GENZ | 245,125 | -14,931 | 13,646,000 | -1,799,000 | $55.67 |
| 03/31/2009 | GENZYME CORP | GENZ | 260,056 | -14,219 | 15,445,000 | -2,759,000 | $59.39 |
| 12/31/2008 | GENZYME CORP | GENZ | 274,275 | 274,275 | 18,204,000 | 18,204,000 | $66.37 |
| 09/30/2008 | GENZYME CORP | GENZ | 288,393 | -2,316 | 23,328,000 | 2,391,000 | $80.89 |
| 06/30/2008 | GENZYME CORP | GENZ | 290,709 | -3,728 | 20,937,000 | -1,010,000 | $72.02 |
| 03/31/2008 | GENZYME CORP | GENZ | 294,437 | 50,606 | 21,947,000 | 3,796,000 | $74.54 |
| 12/31/2007 | GENZYME CORP | GENZ | 243,831 | -6,765 | 18,151,000 | 2,624,000 | $74.44 |
| 09/30/2007 | GENZYME CORP | GENZ | 250,596 | -10,888 | 15,527,000 | -1,313,000 | $61.96 |
| 06/30/2007 | GENZYME CORP | GENZ | 261,484 | 5,469 | 16,840,000 | 1,474,000 | $64.40 |
| 03/31/2007 | GENZYME CORP | GENZ | 256,015 | -30,411 | 15,366,000 | -2,272,000 | $60.02 |
| 12/31/2006 | GENZYME CORP | GENZ | 286,426 | -42,842 | 17,638,000 | -4,578,000 | $61.58 |
| 09/30/2006 | GENZYME CORP | GENZ | 329,268 | 329,268 | 22,216,000 | 22,216,000 | $67.47 |
| 06/30/2006 | GENZYME CORP | GENZ | 319,864 | -226,295 | 19,528,000 | -17,185,000 | $61.05 |
| 03/31/2006 | GENZYME CORP | GENZ | 546,159 | 52,267 | 36,713,000 | 1,755,000 | $67.22 |
| 12/31/2005 | GENZYME CORP | GENZ | 493,892 | 2,467 | 34,958,000 | -248,000 | $70.78 |
| 09/30/2005 | GENZYME CORP | GENZ | 491,425 | 141,316 | 35,206,000 | 14,168,000 | $71.64 |
| 06/30/2005 | GENZYME CORP | GENZ | 479,089 | 213,100 | 28,788,000 | 13,563,000 | $60.09 |
| 03/31/2005 | GENZYME CORP | GENZ | 378,469 | -10,046 | 21,664,000 | -897,000 | $57.24 |
| 12/31/2004 | GENZYME CORP | GENZ | 388,515 | 17,191 | 22,561,000 | 2,357,000 | $58.07 |
| 09/30/2004 | GENZYME CORP | GENZ | 371,324 | -65,662 | 20,204,000 | -478,000 | $54.41 |
| 06/30/2004 | GENZYME CORP | GENZ | 436,986 | 384,454 | 20,682,000 | 18,211,000 | $47.33 |
| 03/31/2004 | GENZYME CORP | GENZ | 52,532 | -337,452 | 2,471,000 | -16,771,000 | $47.04 |
| 12/31/2003 | GENZYME CORP | GENZ | 389,984 | -122,674 | 19,242,000 | -4,468,000 | $49.34 |
| 09/30/2003 | GENZYME CORP | GENZ | 512,658 | 54,977 | 23,710,000 | 4,579,000 | $46.25 |
| 06/30/2003 | GENZYME CORP | GENZ | 457,681 | 3,870 | 19,131,000 | 2,590,000 | $41.80 |
| 03/31/2003 | GENZYME CORP | GENZ | 453,811 | 47,243 | 16,541,000 | 4,519,000 | $36.45 |
| 12/31/2002 | GENZYME CORP | GENZ | 406,568 | -36,790 | 12,022,000 | 2,884,000 | $29.57 |
| 09/30/2002 | GENZYME CORP | GENZ | 443,358 | 13,295 | 9,138,000 | 864,000 | $20.61 |
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