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CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,467,618 | -12,127 | 516,469,450,000 | 50,246,193,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,479,745 | -68,292 | 466,223,257,000 | 19,181,132,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,548,037 | -251,831 | 447,042,125,000 | 446,520,991,000 | $288,780.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,799,868 | -77,220 | 521,134,000 | -7,811,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,877,088 | -25,463 | 528,945,000 | 32,436,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,902,551 | -36,268 | 496,509,000 | 70,744,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,938,819 | -67,499 | 425,765,000 | 61,839,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,006,318 | 11,900 | 363,926,000 | -38,209,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,994,418 | -14,495 | 402,135,000 | -29,560,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,008,913 | -99,555 | 431,695,000 | -66,620,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,108,468 | -52,776 | 498,315,000 | -89,803,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,161,244 | -18,080 | 588,118,000 | -44,562,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,179,324 | 1,596,444 | 632,680,000 | 493,984,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 582,880 | -23,089 | 138,696,000 | 6,019,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 605,969 | 60,781 | 132,677,000 | 40,311,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 545,188 | 153,979 | 92,366,000 | 20,626,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 391,209 | -10,796 | 71,740,000 | -2,209,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 402,005 | -7,903 | 73,949,000 | 6,023,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 409,908 | -31,292 | 67,926,000 | -17,111,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 441,200 | -35,455 | 85,037,000 | 4,025,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 476,655 | -106,582 | 81,012,000 | -6,392,000 | $169.96 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 583,237 | 72,019 | 87,404,000 | 9,678,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 511,218 | 22,818 | 77,726,000 | 14,786,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 488,400 | 20,000 | 62,940,000 | 11,720,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 468,400 | -20,200 | 51,220,000 | 15,225,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 488,600 | 0 | 35,995,000 | -6,616,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 488,600 | -33,500 | 42,611,000 | -406,499,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 522,100 | -16,300 | 44,911,000 | 2,114,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 538,400 | -60,300 | 42,797,000 | -32,537,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 598,700 | 67,000 | 75,334,000 | 35,021,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 598,300 | 0 | 62,307,000 | -11,571,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 598,300 | 18,700 | 73,878,000 | 5,503,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 714,953 | 0 | 88,418,000 | 0 | $123.67 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 714,953 | -32,733 | 88,418,000 | 4,445,000 | $123.67 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 747,686 | 27,996 | 83,973,000 | 36,942,000 | $112.31 |
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