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BIOTECHNOLOGY VALUE FUND L P
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 5,157,486 | 1,658,140 | 161,119,863 | 107,299,921 | $31.24 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 3,499,346 | -17,505 | 53,819,941 | 12,285,931 | $15.38 |
| 06/16/2020 | Xenon Pharmaceuticals Inc. | XENE | 3,516,851 | 860,794 | 41,534,010 | 6,713,103 | $11.81 |
| 12/31/2019 | Xenon Pharmaceuticals Inc. | XENE | 2,656,057 | 53,221 | 34,820,907 | 18,397,012 | $13.11 |
| 12/31/2018 | Xenon Pharmaceuticals Inc. | XENE | 2,602,836 | -265,164 | 16,423,895 | 2,800,895 | $6.31 |
| 03/27/2018 | Xenon Pharmaceuticals Inc. | XENE | 2,868,000 | -720,830 | 13,623,000 | 3,484,555 | $4.75 |
| 12/31/2017 | Xenon Pharmaceuticals Inc. | XENE | 3,588,830 | 3,588,830 | 10,138,445 | 10,138,445 | $2.83 |
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