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CITADEL ADVISORS LLC
> RYTM
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 189,532 | 118,834 | 3,125,383,000 | 1,066,657,000 | $16,490.00 |
| 12/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 70,698 | 14,863 | 2,058,726,000 | 2,057,358,000 | $29,120.00 |
| 09/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 55,835 | -112,223 | 1,368,000 | 670,000 | $24.50 |
| 06/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 168,058 | -81,866 | 698,000 | -2,181,000 | $4.15 |
| 03/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 249,924 | 249,924 | 2,879,000 | 2,879,000 | $11.52 |
| 09/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -32,574 | 0 | -638,000 | |
| 06/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 32,574 | -86,134 | 638,000 | -1,887,000 | $19.59 |
| 03/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 118,708 | 40,662 | 2,525,000 | 205,000 | $21.27 |
| 12/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 78,046 | 49,648 | 2,320,000 | 1,705,000 | $29.73 |
| 09/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 28,398 | 28,398 | 615,000 | 615,000 | $21.66 |
| 06/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -20,758 | 0 | -316,000 | |
| 03/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 20,758 | 20,758 | 316,000 | 316,000 | $15.22 |
| 03/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -14,521 | 0 | -391,000 | |
| 12/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 14,521 | 671 | 391,000 | -13,000 | $26.93 |
| 09/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 13,850 | -36,365 | 404,000 | -1,166,000 | $29.17 |
| 06/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 50,215 | -4,084 | 1,570,000 | 489,000 | $31.27 |
| 03/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 54,299 | -147,529 | 1,081,000 | -4,785,000 | $19.91 |
| 12/31/2017 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 201,828 | 201,828 | 5,866,000 | 5,866,000 | $29.06 |
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