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ESSEX INVESTMENT MANAGEMENT CO LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -10,939 | 0 | -3,446,551,000 | |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,939 | -2,396 | 3,446,551,000 | 3,442,700,000 | $315,070.02 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,335 | -41 | 3,851,000 | -22,000 | $288.79 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,376 | -842 | 3,873,000 | -133,000 | $289.55 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,218 | -666 | 4,006,000 | 122,000 | $281.76 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,884 | -686 | 3,884,000 | 465,000 | $260.95 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,570 | -1,060 | 3,419,000 | 402,000 | $219.59 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,630 | -6,933 | 3,017,000 | -1,734,000 | $181.42 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 23,563 | -2,891 | 4,751,000 | -1,501,000 | $201.63 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 26,454 | -12,550 | 6,252,000 | -4,362,000 | $236.33 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 39,004 | -648 | 10,614,000 | -897,000 | $272.13 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 39,652 | -8,700 | 11,511,000 | 6,000 | $290.30 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 48,352 | -3,183 | 11,505,000 | 221,000 | $237.94 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 51,535 | -144 | 11,284,000 | 2,529,000 | $218.96 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 51,679 | 9,433 | 8,755,000 | 1,008,000 | $169.41 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 42,246 | 0 | 7,747,000 | -24,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 42,246 | -6,704 | 7,771,000 | -341,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 48,950 | -12,607 | 8,112,000 | -3,752,000 | $165.72 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 61,557 | -3,188 | 11,864,000 | 860,000 | $192.73 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 64,745 | 6,745 | 11,004,000 | 1,551,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 58,000 | 136 | 9,453,000 | 782,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 57,864 | 2,936 | 8,671,000 | 320,000 | $149.85 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 54,928 | -2,285 | 8,351,000 | 978,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 57,213 | 19,050 | 7,373,000 | 3,200,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 38,163 | 26,388 | 4,173,000 | 3,306,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,775 | -9,349 | 867,000 | -975,000 | $73.63 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 21,124 | 21,124 | 1,842,000 | 1,842,000 | $87.20 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -6,247 | 0 | -786,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,247 | 1,337 | 786,000 | 414,000 | $125.82 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,807 | 1,897 | 709,000 | 337,000 | $104.16 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,247 | 2,791 | 771,000 | 360,000 | $123.42 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,747 | 3,291 | 796,000 | 385,000 | $117.98 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,456 | -1,454 | 411,000 | 39,000 | $118.92 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,456 | 0 | 388,000 | 61,000 | $112.27 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,456 | -1,454 | 327,000 | -45,000 | $94.62 |
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