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CLOUGH CAPITAL PARTNERS L P
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 26,041 | -10,480 | 9,164,088,000 | -2,342,583,000 | $351,909.99 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 36,521 | 21,840 | 11,506,671,000 | 11,502,420,000 | $315,069.99 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,681 | -1,570 | 4,251,000 | -328,000 | $289.56 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,251 | -41,899 | 4,579,000 | -10,596,000 | $281.77 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 58,150 | -31,460 | 15,175,000 | -1,079,000 | $260.96 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 89,610 | 0 | 16,254,000 | -1,814,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 89,610 | 8,330 | 18,068,000 | 602,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 81,280 | -5,320 | 17,466,000 | -3,001,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 86,600 | 56,000 | 20,467,000 | 11,584,000 | $236.34 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 30,600 | -11,250 | 8,883,000 | -1,075,000 | $290.29 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 41,850 | 5,110 | 9,958,000 | 1,914,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 36,740 | 5,996 | 8,044,000 | 2,835,000 | $218.94 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 30,744 | -300 | 5,209,000 | -484,000 | $169.43 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,044 | -27,405 | 5,693,000 | -5,059,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 58,449 | 13,660 | 10,752,000 | 3,330,000 | $183.96 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 44,789 | -923 | 7,422,000 | -1,389,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 45,712 | -5,500 | 8,811,000 | 107,000 | $192.75 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 51,212 | -7,830 | 8,704,000 | -919,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 59,042 | -6,640 | 9,623,000 | -220,000 | $162.99 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 65,682 | 2,800 | 9,843,000 | 282,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 62,882 | -1,500 | 9,561,000 | 1,264,000 | $152.05 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 64,382 | -44,966 | 8,297,000 | 241,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 109,348 | 0 | 8,056,000 | 0 | $73.67 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 109,348 | 44,448 | 8,056,000 | 2,396,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 64,900 | -18,900 | 5,660,000 | -1,548,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 83,800 | 83,800 | 7,208,000 | 7,208,000 | $86.01 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 101,875 | -67,850 | 8,098,000 | -13,258,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 169,725 | 169,725 | 21,356,000 | 21,356,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 196,950 | 196,950 | 20,510,000 | 20,510,000 | $104.14 |
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