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WELLINGTON MANAGEMENT GROUP LLP
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,552,894 | 35,346 | 2,657,938,927,000 | 289,385,078,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,517,548 | -511,794 | 2,368,553,849,000 | 2,366,229,034,000 | $315,070.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,029,342 | -206,297 | 2,324,815,000 | 4,095,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,235,639 | 181,929 | 2,320,720,000 | 218,944,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,053,710 | 1,535,255 | 2,101,776,000 | 670,322,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,518,455 | 427,366 | 1,431,454,000 | 326,592,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,091,089 | -2,204,600 | 1,104,862,000 | -567,798,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,295,689 | 209,325 | 1,672,660,000 | -65,020,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,086,364 | -1,120,147 | 1,737,680,000 | -438,187,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,206,511 | 3,020,047 | 2,175,867,000 | 492,407,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,186,464 | -275,346 | 1,683,460,000 | -192,467,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,461,810 | -1,149,958 | 1,875,927,000 | 64,706,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,611,768 | 175,609 | 1,811,221,000 | 183,074,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,436,159 | -807,388 | 1,628,147,000 | 231,523,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,243,547 | -15,065 | 1,396,624,000 | -117,841,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,258,612 | -570,173 | 1,514,465,000 | -109,591,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,828,785 | 210,383 | 1,624,056,000 | 195,900,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,618,402 | -887,386 | 1,428,156,000 | -403,988,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,505,788 | -802,611 | 1,832,144,000 | 80,130,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,308,399 | -767,106 | 1,752,014,000 | -53,072,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,075,505 | -1,308,689 | 1,805,086,000 | -50,811,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,384,194 | -883,152 | 1,855,897,000 | -161,271,000 | $149.86 |
| 12/29/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,384,194 | -883,152 | 1,855,895,313 | -161,272,687 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,267,346 | -2,600,854 | 2,017,168,000 | -27,767,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,868,200 | 15,031,918 | 2,044,935,000 | 1,953,488,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 836,282 | -14,083,876 | 91,447,000 | -1,007,720,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,920,158 | 496,319 | 1,099,167,000 | -158,734,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,423,839 | 14,423,839 | 1,257,901,000 | 1,257,901,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,087,647 | 14,087,647 | 1,211,820,000 | 1,211,820,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,727,173 | -136,813 | 1,170,662,000 | -699,674,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,863,986 | 1,405,220 | 1,870,336,000 | 468,739,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,458,766 | -416,455 | 1,401,597,000 | -311,714,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,875,221 | -1,483,538 | 1,713,311,000 | -98,562,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,358,759 | -1,835,273 | 1,811,873,000 | -230,778,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 17,194,032 | -2,664,428 | 2,042,651,000 | -187,653,000 | $118.80 |
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