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WELLINGTON MANAGEMENT GROUP LLP
> ZGEN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2010 | ZYMOGENETICS INC | ZGEN | 4,179,939 | -2,118,973 | 17,640,000 | -18,452,000 | $4.22 |
| 03/31/2010 | ZYMOGENETICS INC | ZGEN | 6,298,912 | 2,483,800 | 36,092,000 | 11,713,000 | $5.73 |
| 12/31/2009 | ZYMOGENETICS INC | ZGEN | 3,815,112 | 152,411 | 24,379,000 | 2,257,000 | $6.39 |
| 09/30/2009 | ZYMOGENETICS INC | ZGEN | 3,662,701 | -259,300 | 22,122,000 | 4,081,000 | $6.04 |
| 06/30/2009 | ZYMOGENETICS INC | ZGEN | 3,922,001 | 35,000 | 18,041,000 | 2,532,000 | $4.60 |
| 03/31/2009 | ZYMOGENETICS INC | ZGEN | 3,887,001 | 259,100 | 15,509,000 | 4,626,000 | $3.99 |
| 12/31/2008 | ZYMOGENETICS INC | ZGEN | 3,627,901 | -727,660 | 10,883,000 | -18,125,000 | $3.00 |
| 09/30/2008 | ZYMOGENETICS INC | ZGEN | 4,355,561 | -1,494,490 | 29,008,000 | -20,250,000 | $6.66 |
| 06/30/2008 | ZYMOGENETICS INC | ZGEN | 5,850,051 | -1,566,625 | 49,258,000 | -23,425,000 | $8.42 |
| 03/31/2008 | ZYMOGENETICS INC | ZGEN | 7,416,676 | 7,416,676 | 72,683,000 | 72,683,000 | $9.80 |
| 12/31/2007 | ZYMOGENETICS INC | ZGEN | 6,616,192 | 6,616,192 | 77,211,000 | 77,211,000 | $11.67 |
| 09/30/2007 | ZYMOGENETICS INC | ZGEN | 6,582,354 | 6,582,354 | 85,899,000 | 85,899,000 | $13.05 |
| 06/30/2007 | ZYMOGENETICS INC | ZGEN | 5,138,954 | 5,138,954 | 75,080,000 | 75,080,000 | $14.61 |
| 03/31/2007 | ZYMOGENETICS INC | ZGEN | 6,657,871 | 6,657,871 | 103,596,000 | 103,596,000 | $15.56 |
| 12/31/2006 | ZYMOGENETICS INC | ZGEN | 6,547,418 | 6,547,418 | 101,944,000 | 101,944,000 | $15.57 |
| 09/30/2006 | ZYMOGENETICS INC | ZGEN | 6,507,818 | 6,507,818 | 109,787,000 | 109,787,000 | $16.87 |
| 06/30/2006 | ZYMOGENETICS INC | ZGEN | 5,853,591 | 5,853,591 | 111,043,000 | 111,043,000 | $18.97 |
| 03/31/2006 | ZYMOGENETICS INC | ZGEN | 5,780,831 | 5,780,831 | 124,981,000 | 124,981,000 | $21.62 |
| 12/31/2005 | ZYMOGENETICS INC | ZGEN | 5,710,756 | 5,710,756 | 97,140,000 | 97,140,000 | $17.01 |
| 09/30/2005 | ZYMOGENETICS INC | ZGEN | 5,765,657 | 5,765,657 | 95,134,000 | 95,134,000 | $16.50 |
| 06/30/2005 | ZYMOGENETICS INC | ZGEN | 5,169,317 | 5,169,317 | 90,982,000 | 90,982,000 | $17.60 |
| 03/31/2005 | ZYMOGENETICS INC | ZGEN | 5,185,917 | 5,185,917 | 79,138,000 | 79,138,000 | $15.26 |
| 12/31/2004 | ZYMOGENETICS INC | ZGEN | 4,857,144 | 4,857,144 | 111,716,000 | 111,716,000 | $23.00 |
| 09/30/2004 | ZYMOGENETICS INC | ZGEN | 5,008,607 | 5,008,607 | 87,352,000 | 87,352,000 | $17.44 |
| 06/30/2004 | ZYMOGENETICS INC | ZGEN | 4,539,357 | 4,539,357 | 86,248,000 | 86,248,000 | $19.00 |
| 03/31/2004 | ZYMOGENETICS INC | ZGEN | 4,323,077 | 4,323,077 | 66,794,000 | 66,794,000 | $15.45 |
| 12/31/2003 | ZYMOGENETICS INC | ZGEN | 3,817,477 | 3,817,477 | 59,170,000 | 59,170,000 | $15.50 |
| 09/30/2003 | ZYMOGENETICS INC | ZGEN | 2,261,877 | 2,261,877 | 33,138,000 | 33,138,000 | $14.65 |
| 06/30/2003 | ZYMOGENETICS INC | ZGEN | 2,490,677 | 2,490,677 | 28,982,000 | 28,982,000 | $11.64 |
| 03/31/2003 | ZYMOGENETICS INC | ZGEN | 2,462,377 | 2,462,377 | 22,650,000 | 22,650,000 | $9.20 |
| 12/31/2002 | ZYMOGENETICS INC | ZGEN | 1,968,400 | 1,968,400 | 19,489,000 | 19,489,000 | $9.90 |
| 09/30/2002 | ZYMOGENETICS INC | ZGEN | 1,108,000 | 1,108,000 | 8,864,000 | 8,864,000 | $8.00 |
| 06/30/2002 | ZYMOGENETICS INC | ZGEN | 979,300 | 979,300 | 8,638,000 | 8,638,000 | $8.82 |
| 03/31/2002 | ZYMOGENETICS INC | ZGEN | 979,300 | 979,300 | 11,057,000 | 11,057,000 | $11.29 |
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