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MORGAN STANLEY
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,780,884 | 202,440 | 978,621,863,000 | 234,018,483,000 | $351,910.35 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,578,444 | 640,899 | 744,603,380,000 | 744,042,384,000 | $288,780.12 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,937,545 | 110,320 | 560,996,000 | 46,102,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,827,225 | 1,001,376 | 514,894,000 | 299,373,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 825,849 | -143,958 | 215,521,000 | 2,551,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 969,807 | -72,706 | 212,970,000 | 23,870,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,042,513 | -178,813 | 189,100,000 | -57,159,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,221,326 | 325,944 | 246,259,000 | 53,852,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 895,382 | -22,466 | 192,407,000 | -24,517,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 917,848 | 144,325 | 216,924,000 | 6,433,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 773,523 | 84,605 | 210,491,000 | 10,491,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 688,918 | 13,423 | 200,000,000 | 39,267,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 675,495 | -95,051 | 160,733,000 | -7,977,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 770,546 | 204,727 | 168,710,000 | 72,848,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 565,819 | 17,022 | 95,862,000 | -4,775,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 548,797 | 37,505 | 100,637,000 | 6,585,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 511,292 | -235,848 | 94,052,000 | -29,756,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 747,140 | 56,373 | 123,808,000 | -9,329,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 690,767 | 69,242 | 133,137,000 | 27,501,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 621,525 | -171,161 | 105,636,000 | -23,556,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 792,686 | -503,385 | 129,192,000 | -65,037,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,296,071 | 461,814 | 194,229,000 | 67,388,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 834,257 | 229,855 | 126,841,000 | 126,774,907 | $152.04 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 604,402 | 325,994 | 66,093 | -20,443,907 | $0.11 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 278,408 | -447,413 | 20,510,000 | -42,790,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 725,821 | 725,821 | 63,300,000 | 63,300,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 196,559 | 196,559 | 16,908,000 | 16,908,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 359,102 | 359,102 | 28,544,000 | 28,544,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 309,826 | 309,826 | 38,986,000 | 38,986,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 197,385 | 197,385 | 20,556,000 | 20,556,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 196,652 | 196,652 | 24,282,000 | 24,282,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 213,088 | 213,088 | 25,137,000 | 25,137,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 284,086 | 284,086 | 33,749,000 | 33,749,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 257,139 | 257,139 | 28,878,000 | 28,878,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 390,939 | 390,939 | 37,014,000 | 37,014,000 | $94.68 |
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