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CLEARBRIDGE, LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -420 | 0 | -81,000 | |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 420 | -45 | 81,000 | 2,000 | $192.86 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 465 | 45 | 79,000 | 11,000 | $169.89 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 420 | 0 | 68,000 | 5,000 | $161.90 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 420 | 0 | 63,000 | -1,000 | $150.00 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 420 | 0 | 64,000 | 10,000 | $152.38 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 420 | -230 | 54,000 | -17,000 | $128.57 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | 0 | 71,000 | 23,000 | $109.23 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | 0 | 48,000 | -9,000 | $73.85 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | 0 | 57,000 | 1,000 | $87.69 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | 650 | 56,000 | 56,000 | $86.15 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | 0 | 52,000 | -30,000 | $80.00 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 650 | -13,900 | 82,000 | -1,433,000 | $126.15 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,550 | -5,650 | 1,515,000 | 14,000 | $104.12 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,550 | -5,650 | 1,797,000 | 296,000 | $123.51 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,050 | -6,150 | 1,657,000 | 156,000 | $117.94 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,050 | -6,150 | 1,669,000 | 168,000 | $118.79 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,050 | -6,150 | 1,578,000 | 77,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,950 | -6,250 | 1,321,000 | -180,000 | $94.70 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,950 | -6,250 | 987,000 | -514,000 | $70.75 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,200 | 20,200 | 1,501,000 | 1,501,000 | $74.31 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,200 | 20,200 | 1,532,000 | 1,532,000 | $75.84 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 25,700 | -17,000 | 2,058,000 | -290,000 | $80.08 |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 42,700 | -7,000 | 2,348,000 | 264,000 | $54.99 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 49,700 | -44,617 | 2,084,000 | -3,188,000 | $41.93 |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 94,317 | -33,587 | 5,272,000 | -1,881,000 | $55.90 |
| 06/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 127,904 | -129,659 | 7,153,000 | -3,410,000 | $55.92 |
| 03/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 257,563 | 257,563 | 10,563,000 | 10,563,000 | $41.01 |
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