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Bank of New York Mellon Corp
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,997,457 | -40,447 | 702,925,210,000 | 60,842,814,000 | $351,910.06 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,037,904 | -44,395 | 642,082,396,000 | 40,756,197,000 | $315,069.99 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,082,299 | 2,082,299 | 601,326,199,000 | 601,326,199,000 | $288,779.95 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,098,301 | 0 | -591,280,000 | |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,098,301 | 95,436 | 591,280,000 | 68,593,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,002,865 | -59,941 | 522,687,000 | 69,694,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,062,806 | -25,982 | 452,993,000 | 74,109,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,088,788 | -25,930 | 378,884,000 | -47,506,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,114,718 | -167,170 | 426,390,000 | -112,912,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,281,888 | 0 | -539,302,000 | |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,281,888 | -315,296 | 539,302,000 | -167,443,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,597,184 | 87,014 | 706,745,000 | -21,982,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,510,170 | 17,545 | 728,727,000 | 135,607,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,492,625 | -16,775 | 593,120,000 | 43,688,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,509,400 | -72,194 | 549,432,000 | 112,057,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,581,594 | 3,444 | 437,375,000 | -35,406,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,578,150 | 296,068 | 472,781,000 | 52,991,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,282,082 | 76,930 | 419,790,000 | 54,374,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,205,152 | -124,886 | 365,416,000 | -83,675,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,330,038 | -557 | 449,091,000 | 52,984,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,330,595 | -21,447 | 396,107,000 | 12,771,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,352,042 | 332,476 | 383,336,000 | 80,683,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,019,566 | 25,156 | 302,653,000 | -577,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,994,410 | 12,454 | 303,230,000 | 47,817,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,981,956 | -102,277 | 255,413,000 | 27,503,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,084,233 | 5,611 | 227,910,000 | 74,776,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,078,622 | -957,092 | 153,134,000 | -111,612,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,035,714 | 3,035,714 | 264,746,000 | 264,746,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,022,436 | -143,602 | 259,990,000 | 8,321,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,166,038 | -432,400 | 251,669,000 | -201,123,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,598,438 | -287,256 | 452,792,000 | 47,952,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,885,694 | -456,855 | 404,840,000 | -131,380,000 | $104.19 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,342,549 | 1,016,876 | 536,220,000 | 221,345,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,467,615 | 556,777 | 527,367,000 | 62,390,000 | $118.04 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,910,838 | 325,584 | 464,977,000 | 62,318,000 | $118.89 |
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