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MAZAMA CAPITAL MANAGEMENT INC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -48,097 | 0 | -6,052,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 48,097 | 48,097 | 6,052,000 | 6,052,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -20,634 | 0 | -2,548,000 | |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,634 | 20,634 | 2,548,000 | 2,548,000 | $123.49 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 56,644 | 56,644 | 6,682,000 | 6,682,000 | $117.96 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 40,605 | 40,605 | 4,824,000 | 4,824,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 47,711 | 47,711 | 5,358,000 | 5,358,000 | $112.30 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -220 | 0 | -16,000 | |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 220 | 220 | 16,000 | 16,000 | $72.73 |
| 03/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -32,155 | 0 | -1,672,000 | |
| 12/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -32,155 | 0 | -1,672,000 | |
| 06/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 32,155 | -88,255 | 1,672,000 | -2,546,000 | $52.00 |
| 12/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 120,410 | -17,065 | 4,218,000 | -535,000 | $35.03 |
| 09/30/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 137,475 | 57,535 | 4,753,000 | 2,122,970 | $34.57 |
| 06/30/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 79,940 | 49,740 | 2,630,030 | 1,396,030 | $32.90 |
| 03/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 30,200 | 30,200 | 1,234,000 | 1,234,000 | $40.86 |
| 09/30/2008 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -1,266,481 | 0 | -30,256,000 | |
| 03/31/2008 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,266,481 | 256,670 | 30,256,000 | 6,798,000 | $23.89 |
| 12/31/2007 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,009,811 | 988,286 | 23,458,000 | 23,117,000 | $23.23 |
| 12/31/2002 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 21,525 | 10,925 | 341,000 | 145,000 | $15.84 |
| 09/30/2002 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,600 | -1,500 | 196,000 | -1,000 | $18.49 |
| 06/30/2002 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,100 | 4,100 | 197,000 | -26,000 | $16.28 |
| 03/31/2002 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,000 | 8,000 | 223,000 | 223,000 | $27.88 |
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