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MASSACHUSETTS FINANCIAL SERVICES CO
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,941,121 | -103,910 | 1,386,919,890,000 | 112,451,973,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,045,031 | -301,700 | 1,274,467,917,000 | 1,273,209,365,000 | $315,070.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,346,731 | 4,619 | 1,258,552,000 | 34,989,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,342,112 | 826,959 | 1,223,563,000 | 306,212,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,515,153 | 320,475 | 917,351,000 | 215,801,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,194,678 | 45,438 | 701,550,000 | 130,309,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,149,240 | -4,547 | 571,241,000 | -64,656,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,153,787 | 519,678 | 635,897,000 | 13,351,000 | $201.63 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,634,109 | 733,952 | 622,546,000 | 105,475,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,900,157 | 91,876 | 517,071,000 | -7,891,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,808,281 | 581,495 | 524,962,000 | 233,048,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,226,786 | 103,158 | 291,914,000 | 45,896,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,123,628 | -96,312 | 246,018,000 | 39,336,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,219,940 | -720,436 | 206,682,000 | -149,144,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,940,376 | -35,218 | 355,826,000 | -7,584,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,975,594 | 64,583 | 363,410,000 | 46,736,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,911,011 | 71,366 | 316,674,000 | -37,900,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,839,645 | 176,093 | 354,574,000 | 71,836,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,663,552 | 143,730 | 282,738,000 | 35,037,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,519,822 | 1,519,822 | 247,701,000 | 247,701,000 | $162.98 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -483,078 | 0 | -60,786,000 | |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -483,078 | 0 | -60,786,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 483,078 | 483,078 | 60,786,000 | 60,786,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 565,520 | 565,520 | 58,895,000 | 58,895,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 547,051 | 105,748 | 67,549,857,000 | 15,489,342,000 | $123,480.00 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 441,303 | 441,303 | 52,060,515,000 | 52,060,515,000 | $117,970.00 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 692,168 | 692,168 | 82,229,558,000 | 82,229,558,000 | $118,800.00 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 514,156 | 514,156 | 57,746,000 | 57,746,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -78,710 | 0 | -5,566,371,000 | |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 78,710 | 78,710 | 5,566,371,000 | 5,566,371,000 | $70,720.00 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 80,150 | 80,150 | 5,955,145,000 | 5,955,145,000 | $74,300.00 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 81,160 | -1,180 | 6,153,551,000 | -438,589,000 | $75,820.00 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 82,340 | 82,340 | 6,592,140,000 | 6,592,140,000 | $80,060.00 |
| 12/31/2005 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -248,960 | 0 | -5,564,256 | |
| 09/30/2005 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 248,960 | 248,960 | 5,564,256 | 5,564,256 | $22.35 |
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