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MILLENNIUM MANAGEMENT LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,066,718 | 730,156 | 375,388,731,000 | 375,291,539,000 | $351,910.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 336,562 | 333,024 | 97,192,000 | 96,168,000 | $288.78 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,538 | -287,965 | 1,024,000 | -81,119,000 | $289.43 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 291,503 | -21,633 | 82,143,000 | 424,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 313,136 | -133,717 | 81,719,000 | -16,410,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 446,853 | -248,855 | 98,129,000 | -28,065,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 695,708 | 331,296 | 126,194,000 | 52,718,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 364,412 | -541,509 | 73,476,000 | -121,197,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 905,921 | 592,174 | 194,673,000 | 120,522,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 313,747 | 162,806 | 74,151,000 | 30,331,000 | $236.34 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 150,941 | 57,693 | 43,820,000 | 21,632,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 93,248 | -304,556 | 22,188,000 | -64,911,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 397,804 | -3,685 | 87,099,000 | 19,079,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 401,489 | -99,114 | 68,020,000 | -23,781,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 500,603 | -109,608 | 91,801,000 | -20,447,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 610,211 | -620,640 | 112,248,000 | -91,716,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,230,851 | 222,524 | 203,964,000 | 9,619,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,008,327 | 344,730 | 194,345,000 | 81,560,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 663,597 | 95,048 | 112,785,000 | 20,123,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 568,549 | -659,534 | 92,662,000 | -91,379,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,228,083 | -440,125 | 184,041,000 | -69,593,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,668,208 | 890,742 | 253,634,000 | 153,442,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 777,466 | 777,466 | 100,192,000 | 100,192,000 | $128.87 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -259,941 | 0 | -20,811,000 | |
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