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MILLENNIUM MANAGEMENT LLC
> SPRB
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | 577,658 | 430,162 | 1,241,965,000 | 1,241,803,000 | $2,150.00 |
| 12/31/2022 | SPRUCE BIOSCIENCES, INC. | SPRB | 147,496 | 2,481 | 162,000 | -37,000 | $1.10 |
| 09/30/2022 | SPRUCE BIOSCIENCES, INC. | SPRB | 145,015 | -45,132 | 199,000 | -132,000 | $1.37 |
| 06/30/2022 | SPRUCE BIOSCIENCES, INC. | SPRB | 190,147 | 190,147 | 331,000 | 331,000 | $1.74 |
| 12/31/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 0 | -38,622 | 0 | -232,000 | |
| 09/30/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 38,622 | 21,406 | 232,000 | 39,000 | $6.01 |
| 06/30/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 17,216 | -55,865 | 193,000 | -1,020,000 | $11.21 |
| 03/31/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 73,081 | -51,627 | 1,213,000 | -1,819,000 | $16.60 |
| 12/31/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | 124,708 | 124,708 | 3,032,000 | 3,032,000 | $24.31 |
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