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MILLENNIUM MANAGEMENT LLC
> SPRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Spero Therapeutics, Inc. | SPRO | 373,850 | -502,548 | 542,082,000 | 540,566,000 | $1,450.00 |
| 12/31/2022 | Spero Therapeutics, Inc. | SPRO | 876,398 | 188,002 | 1,516,000 | 139,000 | $1.73 |
| 09/30/2022 | Spero Therapeutics, Inc. | SPRO | 688,396 | 373,753 | 1,377,000 | 1,144,000 | $2.00 |
| 06/30/2022 | Spero Therapeutics, Inc. | SPRO | 314,643 | 253,382 | 233,000 | -300,000 | $0.74 |
| 03/31/2022 | Spero Therapeutics, Inc. | SPRO | 61,261 | 61,261 | 533,000 | 533,000 | $8.70 |
| 06/30/2021 | Spero Therapeutics, Inc. | SPRO | 0 | -12,635 | 0 | -186,000 | |
| 03/31/2021 | Spero Therapeutics, Inc. | SPRO | 12,635 | -45,427 | 186,000 | -940,000 | $14.72 |
| 12/31/2020 | Spero Therapeutics, Inc. | SPRO | 58,062 | 22,069 | 1,126,000 | 639,000 | $19.39 |
| 06/30/2020 | Spero Therapeutics, Inc. | SPRO | 35,993 | 21,938 | 487,000 | 373,000 | $13.53 |
| 03/31/2020 | Spero Therapeutics, Inc. | SPRO | 14,055 | 1,373 | 114,000 | -8,000 | $8.11 |
| 12/31/2019 | Spero Therapeutics, Inc. | SPRO | 12,682 | 12,682 | 122,000 | 122,000 | $9.62 |
| 06/30/2018 | Spero Therapeutics, Inc. | SPRO | 0 | -11,415 | 0 | -163,000 | |
| 03/31/2018 | Spero Therapeutics, Inc. | SPRO | 11,415 | 11,415 | 163,000 | 163,000 | $14.28 |
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