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MILLENNIUM MANAGEMENT LLC
> AGLE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 2,453,221 | -678,258 | 1,105,176,000 | 1,103,767,000 | $450.50 |
| 12/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 3,131,479 | 2,316,807 | 1,409,000 | 980,000 | $0.45 |
| 09/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 814,672 | 292,757 | 429,000 | 165,000 | $0.53 |
| 06/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 521,915 | 98,001 | 264,000 | -711,000 | $0.51 |
| 03/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 423,914 | 233,432 | 975,000 | 70,000 | $2.30 |
| 12/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 190,482 | -344,740 | 905,000 | -3,350,000 | $4.75 |
| 09/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 535,222 | -7,963 | 4,255,000 | 474,000 | $7.95 |
| 06/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 543,185 | 172,049 | 3,781,000 | 842,000 | $6.96 |
| 03/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 371,136 | -88,022 | 2,939,000 | -675,000 | $7.92 |
| 12/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 459,158 | 275,708 | 3,614,000 | 1,917,000 | $7.87 |
| 06/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 183,450 | 169,516 | 1,697,000 | 1,632,000 | $9.25 |
| 03/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 13,934 | 13,934 | 65,000 | 65,000 | $4.66 |
| 09/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 0 | -75,884 | 0 | -520,000 | |
| 06/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 75,884 | 61,366 | 520,000 | 403,000 | $6.85 |
| 03/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 14,518 | -6,366 | 117,000 | -39,000 | $8.06 |
| 12/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 20,884 | 20,884 | 156,000 | 156,000 | $7.47 |
| 09/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 0 | -476,478 | 0 | -5,041,000 | |
| 06/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 476,478 | 402,288 | 5,041,000 | 4,305,000 | $10.58 |
| 03/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 74,190 | 60,361 | 736,000 | 661,000 | $9.92 |
| 12/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 13,829 | 13,829 | 75,000 | 75,000 | $5.42 |
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