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MILLENNIUM MANAGEMENT LLC
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 1,151,241 | 799,698 | 2,060,721,000 | 2,059,526,000 | $1,790.00 |
| 12/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 351,543 | 88,857 | 1,195,000 | -239,000 | $3.40 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 262,686 | -342,697 | 1,434,000 | -1,296,000 | $5.46 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 605,383 | -647,490 | 2,730,000 | -6,504,000 | $4.51 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 1,252,873 | -267,351 | 9,234,000 | -541,000 | $7.37 |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 1,520,224 | 1,520,224 | 9,775,000 | 9,775,000 | $6.43 |
| 09/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 0 | -115,013 | 0 | -1,187,000 | |
| 06/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 115,013 | -624,701 | 1,187,000 | -6,595,000 | $10.32 |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 739,714 | -1,755,187 | 7,782,000 | -30,839,000 | $10.52 |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 2,494,901 | 2,257,211 | 38,621,000 | 34,119,000 | $15.48 |
| 06/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 237,690 | 237,690 | 4,502,000 | 4,502,000 | $18.94 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 0 | -13,496 | 0 | -259,000 | |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 13,496 | -1,272,203 | 259,000 | -12,109,000 | $19.19 |
| 09/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 1,285,699 | 1,213,044 | 12,368,000 | 11,933,000 | $9.62 |
| 06/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 72,655 | -2,647,059 | 435,000 | -15,448,000 | $5.99 |
| 03/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 2,719,714 | 2,272,107 | 15,883,000 | 11,689,000 | $5.84 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 447,607 | -388,334 | 4,194,000 | -10,042,000 | $9.37 |
| 09/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 835,941 | -203,528 | 14,236,000 | -3,425,000 | $17.03 |
| 06/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 1,039,469 | -232,799 | 17,661,000 | 587,000 | $16.99 |
| 03/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 1,272,268 | 835,432 | 17,074,000 | 12,880,000 | $13.42 |
| 12/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 436,836 | 65,920 | 4,194,000 | 121,000 | $9.60 |
| 09/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 370,916 | 151,759 | 4,073,000 | 2,090,000 | $10.98 |
| 06/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 219,157 | 219,157 | 1,983,000 | 1,983,000 | $9.05 |
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