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KOPP INVESTMENT ADVISORS LLC
> LGND
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2019 | LIGAND PHARMACEUTICALS INC | LGND | 10,578 | -3,685 | 1,053,000 | -575,000 | $99.55 |
| 06/30/2019 | LIGAND PHARMACEUTICALS INC | LGND | 14,263 | -4,928 | 1,628,000 | -785,000 | $114.14 |
| 03/31/2019 | LIGAND PHARMACEUTICALS INC | LGND | 19,191 | -149 | 2,413,000 | -211,000 | $125.74 |
| 12/31/2018 | LIGAND PHARMACEUTICALS INC | LGND | 19,340 | -137 | 2,624,000 | -2,722,000 | $135.68 |
| 09/30/2018 | LIGAND PHARMACEUTICALS INC | LGND | 19,477 | -3,659 | 5,346,000 | 553,000 | $274.48 |
| 06/30/2018 | LIGAND PHARMACEUTICALS INC | LGND | 23,136 | 1,731 | 4,793,000 | 1,258,000 | $207.17 |
| 03/31/2018 | LIGAND PHARMACEUTICALS INC | LGND | 21,405 | -621 | 3,535,000 | 519,000 | $165.15 |
| 12/31/2017 | LIGAND PHARMACEUTICALS INC | LGND | 22,026 | -20 | 3,016,000 | 14,000 | $136.93 |
| 09/30/2017 | LIGAND PHARMACEUTICALS INC | LGND | 22,046 | -370 | 3,002,000 | 281,000 | $136.17 |
| 06/30/2017 | LIGAND PHARMACEUTICALS INC | LGND | 22,416 | -1,148 | 2,721,000 | 227,000 | $121.39 |
| 03/31/2017 | LIGAND PHARMACEUTICALS INC | LGND | 23,564 | -221 | 2,494,000 | 77,000 | $105.84 |
| 12/31/2016 | LIGAND PHARMACEUTICALS INC | LGND | 23,785 | 327 | 2,417,000 | 23,000 | $101.62 |
| 09/30/2016 | LIGAND PHARMACEUTICALS INC | LGND | 23,458 | -6,959 | 2,394,000 | -1,234,000 | $102.05 |
| 06/30/2016 | LIGAND PHARMACEUTICALS INC | LGND | 30,417 | 30,417 | 3,628,000 | 3,628,000 | $119.28 |
| 03/31/2016 | LIGAND PHARMACEUTICALS INC | LGND | 31,134 | 644 | 3,334,000 | 28,000 | $107.09 |
| 12/31/2015 | LIGAND PHARMACEUTICALS INC | LGND | 30,490 | -1,018 | 3,306,000 | 607,000 | $108.43 |
| 09/30/2015 | LIGAND PHARMACEUTICALS INC | LGND | 31,508 | 3,664 | 2,699,000 | -110,000 | $85.66 |
| 06/30/2015 | LIGAND PHARMACEUTICALS INC | LGND | 27,844 | 27,844 | 2,809,000 | 2,809,000 | $100.88 |
| 03/31/2015 | LIGAND PHARMACEUTICALS INC | LGND | 24,501 | 24,501 | 1,889,000 | 1,889,000 | $77.10 |
| 12/31/2014 | LIGAND PHARMACEUTICALS INC | LGND | 23,731 | 23,731 | 1,263,000 | 1,263,000 | $53.22 |
| 09/30/2014 | LIGAND PHARMACEUTICALS INC | LGND | 18,368 | 18,368 | 863,000 | 863,000 | $46.98 |
| 06/30/2014 | LIGAND PHARMACEUTICALS INC | LGND | 18,847 | 18,847 | 1,174,000 | 1,174,000 | $62.29 |
| 03/31/2014 | LIGAND PHARMACEUTICALS INC | LGND | 5,012 | 5,012 | 337,000 | 337,000 | $67.24 |
| 12/31/2013 | LIGAND PHARMACEUTICALS INC | LGND | 4,004 | 4,004 | 211,000 | 211,000 | $52.70 |
| 09/30/2013 | LIGAND PHARMACEUTICALS INC | LGND | 43,139 | 43,139 | 1,867,000 | 1,867,000 | $43.28 |
| 06/30/2013 | LIGAND PHARMACEUTICALS INC | LGND | 49,379 | 13,359 | 1,847,000 | 887,000 | $37.40 |
| 03/31/2013 | LIGAND PHARMACEUTICALS INC | LGND | 36,020 | -1,745 | 960,000 | 177,000 | $26.65 |
| 12/31/2012 | LIGAND PHARMACEUTICALS INC | LGND | 37,765 | 4,755 | 783,000 | 217,000 | $20.73 |
| 09/30/2012 | LIGAND PHARMACEUTICALS INC | LGND | 33,010 | 2,645 | 566,000 | 52,000 | $17.15 |
| 06/30/2012 | LIGAND PHARMACEUTICALS INC | LGND | 30,365 | 30,365 | 514,000 | 514,000 | $16.93 |
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