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WORLDQUANT MILLENNIUM ADVISORS LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 140,665 | 52,383 | 49,501,420,000 | 49,475,926,000 | $351,910.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 88,282 | 56,520 | 25,494,000 | 16,298,000 | $288.78 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,762 | 23,055 | 9,196,000 | 6,742,000 | $289.53 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,707 | 8,707 | 2,454,000 | 2,454,000 | $281.84 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -122,737 | 0 | -22,263,000 | |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 122,737 | -13,726 | 22,263,000 | -5,252,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 136,463 | 31,363 | 27,515,000 | 4,930,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 105,100 | 9,778 | 22,585,000 | 57,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 95,322 | 0 | 22,528,000 | -3,411,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 95,322 | 1,023 | 25,939,000 | -1,437,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 94,299 | 58,172 | 27,376,000 | 18,780,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 36,127 | -143,959 | 8,596,000 | -21,914,000 | $237.94 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 180,086 | -278,140 | 30,510,000 | -53,519,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 458,226 | 63,941 | 84,029,000 | 11,500,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 394,285 | 40,802 | 72,529,000 | 13,953,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 353,483 | 86,440 | 58,576,000 | 7,106,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 267,043 | 96,331 | 51,470,000 | 22,456,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 170,712 | 170,712 | 29,014,000 | 29,014,000 | $169.96 |
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