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AMERIPRISE FINANCIAL INC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,023,843 | -366,017 | 1,064,140,025,000 | -3,885,117,000 | $351,916.43 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,389,860 | -188,787 | 1,068,025,142,000 | 34,587,142,000 | $315,064.68 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,578,647 | -463,346 | 1,033,438,000,000 | 1,032,267,448,000 | $288,778.97 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,041,993 | -520,956 | 1,170,552,000 | -114,947,000 | $289.60 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,562,949 | -384,414 | 1,285,499,000 | -4,638,000 | $281.73 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,947,363 | 524,167 | 1,290,137,000 | 320,966,000 | $260.77 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,423,196 | 1,034,106 | 969,171,000 | 354,467,000 | $219.11 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,389,090 | 650,315 | 614,704,000 | 62,503,000 | $181.38 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,738,775 | 820,708 | 552,201,000 | 140,039,000 | $201.62 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,918,067 | 1,100,467 | 412,162,000 | 218,970,000 | $214.88 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 817,600 | -22,268 | 193,192,000 | -35,224,000 | $236.29 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 839,868 | -444,227 | 228,416,000 | -144,365,000 | $271.97 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,284,095 | -888,799 | 372,781,000 | -144,265,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,172,894 | -236,171 | 517,046,000 | -10,254,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,409,065 | 30,299 | 527,300,000 | 124,319,000 | $218.88 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,378,766 | -62,955 | 402,981,000 | -44,776,000 | $169.41 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,441,721 | 78,258 | 447,757,000 | 13,132,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,363,463 | -1,986,539 | 434,625,000 | -286,041,000 | $183.89 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,350,002 | -1,393,382 | 720,666,000 | -384,810,000 | $165.67 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,743,384 | -82,081 | 1,105,476,000 | 117,840,000 | $192.48 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,825,465 | 220,446 | 987,636,000 | 74,136,000 | $169.54 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,605,019 | 349,639 | 913,500,000 | 126,608,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,255,380 | -176,700 | 786,892,000 | -38,980,000 | $149.73 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,432,080 | -973,672 | 825,872,000 | 360,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,405,752 | -1,832,449 | 825,512,000 | -75,572,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,238,201 | -468,434 | 901,084,000 | 259,609,000 | $109.38 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,706,635 | 11,204 | 641,475,000 | -116,852,000 | $73.68 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,695,431 | 8,695,431 | 758,327,000 | 758,327,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,024,075 | -379,072 | 776,208,000 | 28,743,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,403,147 | -187,047 | 747,465,000 | -459,289,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,590,194 | 276,375 | 1,206,754,000 | 100,287,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,161,397 | 847,578 | 1,058,033,000 | -48,434,000 | $104.12 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,874,561 | 560,742 | 1,219,257,000 | 112,790,000 | $123.47 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,955,894 | 642,075 | 1,174,524,000 | 68,057,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,313,819 | 2,235,244 | 1,106,467,000 | 436,271,000 | $118.80 |
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