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Jefferies Group LLC
> ALNY
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 93,600 | 61,500 | 18,735,000 | 14,053,000 | $200.16 |
| 06/30/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 32,100 | 12,500 | 4,682,000 | 1,482,000 | $145.86 |
| 03/31/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 19,600 | -34,600 | 3,200,000 | -5,991,000 | $163.27 |
| 12/31/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 54,200 | 30,000 | 9,191,000 | 4,622,000 | $169.58 |
| 09/30/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 24,200 | 4,200 | 4,569,000 | 1,179,000 | $188.80 |
| 06/30/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 20,000 | 20,000 | 3,390,000 | 3,390,000 | $169.50 |
| 03/31/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -30,300 | 0 | -3,938,000 | |
| 12/31/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 30,300 | -30,000 | 3,938,000 | -4,842,000 | $129.97 |
| 09/30/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 60,300 | 300 | 8,780,000 | -107,000 | $145.61 |
| 06/30/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 60,000 | 0 | 8,887,000 | 2,356,000 | $148.12 |
| 03/31/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 60,000 | 60,000 | 6,531,000 | 6,531,000 | $108.85 |
| 12/31/2019 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -15,000 | 0 | -1,206,000 | |
| 09/30/2019 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 15,000 | 15,000 | 1,206,000 | 1,206,000 | $80.40 |
| 12/31/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -9,800 | 0 | -858,000 | |
| 09/30/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 9,800 | 9,800 | 858,000 | 858,000 | $87.55 |
| 06/30/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -45,000 | 0 | -5,717,000 | |
| 12/31/2017 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 45,000 | -96,300 | 5,717,000 | -10,884,000 | $127.04 |
| 09/30/2017 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 141,300 | 141,300 | 16,601,000 | 16,601,000 | $117.49 |
| 06/30/2016 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -3,600 | 0 | -226,000 | |
| 03/31/2016 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 3,600 | -13,300 | 226,000 | -1,132,000 | $62.78 |
| 12/31/2015 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 16,900 | 0 | 1,591,000 | 233,000 | $94.14 |
| 09/30/2015 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 16,900 | 16,900 | 1,358,000 | 1,358,000 | $80.36 |
| 06/30/2015 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 9,000 | 9,000 | 1,079,000 | 1,079,000 | $119.89 |
| 06/30/2014 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -47,600 | 0 | -3,196,000 | |
| 03/31/2014 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 47,600 | 47,600 | 3,196,000 | 3,196,000 | $67.14 |
| 06/30/2013 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 0 | -65,000 | 0 | -1,584,000 | |
| 03/31/2013 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | 65,000 | 65,000 | 1,584,000 | 1,584,000 | $24.37 |
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