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MANNING & NAPIER ADVISORS LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 885,868 | -745,258 | 134,686,000 | -75,515,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,631,126 | -133,293 | 210,201,000 | 17,263,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,764,419 | -361,601 | 192,938,000 | 36,315,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,126,020 | 1,983,480 | 156,623,000 | 144,193,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 142,540 | 15,550 | 12,430,000 | 1,508,000 | $87.20 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 126,990 | 126,990 | 10,922,000 | 10,922,000 | $86.01 |
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