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LOS ANGELES CAPITAL MANAGEMENT LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 426,228 | -30,927 | 149,993,895,000 | 5,958,069,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 457,155 | 22,629 | 144,035,826,000 | 143,910,013,000 | $315,070.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 434,526 | 97,060 | 125,813,000 | 30,718,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 337,466 | -17,352 | 95,095,000 | 2,498,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 354,818 | 52,813 | 92,597,000 | 26,277,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 302,005 | 132,648 | 66,320,000 | 32,173,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 169,357 | 0 | 34,147,000 | 0 | $201.63 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 169,357 | -137,707 | 34,147,000 | -38,425,000 | $201.63 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 307,064 | -9,251 | 72,572,000 | -13,504,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 316,315 | -16,597 | 86,076,000 | -10,572,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 332,912 | 22,412 | 96,648,000 | 22,765,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 310,500 | 4,390 | 73,883,000 | 6,860,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 306,110 | -77,453 | 67,023,000 | 2,040,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 383,563 | -50,423 | 64,983,000 | -14,601,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 433,986 | -1,000 | 79,584,000 | -432,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 434,986 | -7,000 | 80,016,000 | 6,774,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 441,986 | -98,831 | 73,242,000 | -30,995,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 540,817 | 1,659 | 104,237,000 | 12,602,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 539,158 | 222,318 | 91,635,000 | 39,996,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 316,840 | -2,680 | 51,639,000 | 3,756,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 319,520 | 234,181 | 47,883,000 | 34,908,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 85,339 | 81,727 | 12,975,000 | 12,510,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,612 | 3,612 | 465,000 | 465,000 | $128.74 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -23,268 | 0 | -1,714,000 | |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 23,268 | -154,012 | 1,714,000 | -13,747,000 | $73.66 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 177,280 | -11,821 | 15,461,000 | -805,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 189,101 | 189,101 | 16,266,000 | 16,266,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,114 | 0 | -266,000 | |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,114 | -111,740 | 266,000 | -8,193,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,436 | -78,308 | 462,000 | -5,390,000 | $104.15 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 329,565 | 327,051 | 40,695,000 | 40,457,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 312,315 | 309,801 | 36,844,000 | 36,562,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,514 | 0 | 299,000 | 17,000 | $118.93 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,514 | 0 | 282,000 | 44,000 | $112.17 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,514 | -80,230 | 238,000 | -5,614,000 | $94.67 |
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