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ARK Investment Management LLC
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 2,422,631 | -250,907 | 99,400,562,000 | -1,578,968,000 | $41,030.00 |
| 12/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 2,673,538 | -1,039,569 | 100,979,530,000 | 100,815,299,000 | $37,770.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 3,713,107 | -988,190 | 164,231,000 | -7,460,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 4,701,297 | -2,381,959 | 171,691,000 | -43,852,000 | $36.52 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 7,083,256 | -1,428,128 | 215,543,480 | -69,928,520 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 8,511,384 | -396,349 | 285,472,000 | -69,857,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 8,907,733 | 6,508,179 | 355,329,000 | 219,658,000 | $39.89 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 2,399,554 | 1,896,994 | 135,671,000 | 111,825,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 502,560 | 158,429 | 23,846,000 | 3,556,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 344,131 | 224,450 | 20,290,000 | 14,631,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 119,681 | -96,344 | 5,659,000 | -7,391,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 216,025 | 19,356 | 13,050,000 | 1,268,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 196,669 | 38,896 | 11,782,000 | 1,642,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 157,773 | -7,205 | 10,140,000 | -3,251,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 164,978 | -77,334 | 13,391,000 | 292,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 242,312 | 12,994 | 13,099,000 | 1,271,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 229,318 | 16,191 | 11,828,000 | 2,947,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 213,127 | -138,778 | 8,881,000 | -6,631,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 351,905 | -18,930 | 15,512,000 | -3,141,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 370,835 | 123,372 | 18,653,000 | 6,107,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 247,463 | 70,472 | 12,546,000 | 3,542,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 176,991 | 49,428 | 9,004,000 | 3,876,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 127,563 | 127,563 | 5,128,000 | 5,128,000 | $40.20 |
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