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DEUTSCHE BANK AG\
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 577,975 | -11,996 | 16,368,252,000 | 2,816,618,000 | $28,320.00 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 589,971 | 7,777 | 13,551,634,000 | 13,535,170,000 | $22,970.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 582,194 | 23,098 | 16,464,000 | 4,068,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 559,096 | -1,757 | 12,396,000 | -3,931,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 560,853 | -10,363 | 16,327,000 | -2,449,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 571,216 | -101,216 | 18,776,000 | -12,257,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 672,432 | -35,594 | 31,033,000 | -5,529,000 | $46.15 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 708,026 | -38,565 | 36,562,000 | 4,212,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 746,591 | 304,601 | 32,350,000 | 16,881,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 441,990 | -53,903 | 15,469,000 | -11,051,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 495,893 | -60,889 | 26,520,000 | 6,765,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 556,782 | 5,837 | 19,755,000 | -6,550,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 550,945 | -72,635 | 26,305,000 | 6,102,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 623,580 | -38,090 | 20,203,000 | -12,798,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 661,670 | 309,981 | 33,001,000 | 9,286,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 351,689 | 10,650 | 23,715,000 | 7,992,000 | $67.43 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 341,039 | 21,937 | 15,723,000 | -8,884,000 | $46.10 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 390,674 | -120,980 | 30,129,000 | -12,967,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 511,654 | -97,298 | 43,096,000 | -6,701,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 608,952 | 438,490 | 49,797,000 | 40,055,000 | $81.77 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 170,462 | 22,721 | 9,742,000 | -117,000 | $57.15 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 147,741 | -113,161 | 9,859,000 | -3,563,000 | $66.73 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 260,902 | 94,822 | 13,422,000 | 3,726,000 | $51.44 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 166,080 | 20,876 | 9,696,000 | 3,639,000 | $58.38 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 145,204 | -57,976 | 6,057,000 | -4,671,000 | $41.71 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 203,180 | -34,955 | 10,728,000 | 753,000 | $52.80 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 238,135 | 150,511 | 9,975,000 | 6,420,000 | $41.89 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 87,624 | 48,589 | 3,555,000 | 1,025,000 | $40.57 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 39,035 | -15,115 | 2,530,000 | -1,289,000 | $64.81 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 54,150 | 2,916 | 3,819,000 | -1,872,000 | $70.53 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 51,234 | 51,234 | 5,691,000 | 5,691,000 | $111.08 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 95,698 | 95,698 | 9,021,000 | 9,021,000 | $94.27 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 174,752 | 174,752 | 19,576,000 | 19,576,000 | $112.02 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 100,065 | 100,065 | 6,137,000 | 6,137,000 | $61.33 |
| 06/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 91,226 | 91,226 | 4,179,000 | 4,179,000 | $45.81 |
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