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STATE STREET CORP
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,331,593 | -38,837 | 4,339,610,893,000 | 767,278,118,000 | $351,910.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,370,430 | 75,639 | 3,572,332,775,000 | 3,568,772,941,000 | $288,780.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,294,791 | 30,742 | 3,559,834,000 | 103,948,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,264,049 | 211,286 | 3,455,886,000 | 310,476,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,052,763 | -304,152 | 3,145,410,000 | 431,831,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,356,915 | 33,499 | 2,713,579,000 | 478,235,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,323,416 | 617,593 | 2,235,344,000 | -124,901,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,705,823 | 530,785 | 2,360,245,000 | -41,159,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,175,038 | -261,026 | 2,401,404,000 | -301,395,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,436,064 | 74,118 | 2,702,799,000 | -389,014,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,361,946 | -306,299 | 3,091,813,000 | -295,595,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,668,245 | 219,002 | 3,387,408,000 | 663,061,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,449,243 | 54,718 | 2,724,347,000 | 229,516,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,394,525 | 80,917 | 2,494,831,000 | 578,080,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,313,608 | -60,634 | 1,916,751,000 | -169,057,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,374,242 | -109,804 | 2,085,808,000 | -26,682,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,484,046 | 643,769 | 2,112,490,000 | 316,148,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,840,277 | -53,978 | 1,796,342,000 | -303,416,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,894,255 | 404,711 | 2,099,758,000 | 316,955,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,489,544 | -486,519 | 1,782,803,000 | 137,926,000 | $169.96 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,976,063 | -242,464 | 1,644,877,000 | -60,792,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,218,527 | -140,623 | 1,705,669,000 | 241,823,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,359,150 | -654,028 | 1,463,846,000 | 150,199,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,013,178 | 239,017 | 1,313,647,000 | 446,254,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,774,161 | 308,574 | 867,393,000 | -132,524,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,465,587 | 1,639,879 | 999,917,000 | 154,703,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,825,708 | 35,700 | 845,214,000 | 67,000,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,790,008 | 118,792 | 778,214,000 | -228,935,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,801,580 | 130,364 | 1,233,325,000 | 226,176,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,671,216 | 20,073 | 1,007,149,000 | -184,575,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,651,143 | -301,592 | 1,191,724,000 | 17,587,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,952,735 | -303,130 | 1,174,137,000 | -44,264,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,255,865 | 502,104 | 1,218,401,000 | 122,951,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,753,761 | -208,163 | 1,095,450,000 | 152,257,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,961,924 | -132,443 | 943,193,000 | 229,317,000 | $94.68 |
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