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STATE STREET CORP
> SPRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Spero Therapeutics, Inc. | SPRO | 110,711 | 0 | 160,531,000 | -30,999,000 | $1,450.00 |
| 12/31/2022 | Spero Therapeutics, Inc. | SPRO | 110,711 | 19,400 | 191,530,000 | 191,347,000 | $1,730.00 |
| 09/30/2022 | Spero Therapeutics, Inc. | SPRO | 91,311 | -9,073 | 183,000 | 109,000 | $2.00 |
| 06/30/2022 | Spero Therapeutics, Inc. | SPRO | 100,384 | -396,801 | 74,000 | -4,252,000 | $0.74 |
| 03/31/2022 | Spero Therapeutics, Inc. | SPRO | 497,185 | -346,770 | 4,326,000 | -9,186,000 | $8.70 |
| 12/31/2021 | Spero Therapeutics, Inc. | SPRO | 843,955 | 41,264 | 13,512,000 | -1,266,000 | $16.01 |
| 09/30/2021 | Spero Therapeutics, Inc. | SPRO | 802,691 | -8,047 | 14,778,000 | 3,460,000 | $18.41 |
| 06/30/2021 | Spero Therapeutics, Inc. | SPRO | 810,738 | -545,805 | 11,318,000 | -8,650,000 | $13.96 |
| 03/31/2021 | Spero Therapeutics, Inc. | SPRO | 1,356,543 | 1,017,712 | 19,968,000 | 13,398,000 | $14.72 |
| 12/31/2020 | Spero Therapeutics, Inc. | SPRO | 338,831 | 53,239 | 6,570,000 | 3,383,000 | $19.39 |
| 09/30/2020 | Spero Therapeutics, Inc. | SPRO | 285,592 | -2,982 | 3,187,000 | -717,000 | $11.16 |
| 06/30/2020 | Spero Therapeutics, Inc. | SPRO | 288,574 | 10,131 | 3,904,000 | 1,654,000 | $13.53 |
| 03/31/2020 | Spero Therapeutics, Inc. | SPRO | 278,443 | 69,852 | 2,250,000 | 244,000 | $8.08 |
| 12/31/2019 | Spero Therapeutics, Inc. | SPRO | 208,591 | 11,365 | 2,006,000 | -85,000 | $9.62 |
| 09/30/2019 | Spero Therapeutics, Inc. | SPRO | 197,226 | 27,695 | 2,091,000 | 140,000 | $10.60 |
| 06/30/2019 | Spero Therapeutics, Inc. | SPRO | 169,531 | 60,396 | 1,951,000 | 553,000 | $11.51 |
| 03/31/2019 | Spero Therapeutics, Inc. | SPRO | 109,135 | -42,958 | 1,398,000 | 463,000 | $12.81 |
| 12/31/2018 | Spero Therapeutics, Inc. | SPRO | 152,093 | 24,168 | 935,000 | -409,000 | $6.15 |
| 09/30/2018 | Spero Therapeutics, Inc. | SPRO | 127,925 | 66,727 | 1,344,000 | 446,000 | $10.51 |
| 06/30/2018 | Spero Therapeutics, Inc. | SPRO | 61,198 | 61,198 | 898,000 | 898,000 | $14.67 |
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