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STATE STREET CORP
> RYTM
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,267,425 | 86,727 | 53,879,838,000 | -38,742,088,000 | $16,490.00 |
| 12/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,180,698 | 52,793 | 92,621,926,000 | 92,545,292,000 | $29,120.00 |
| 09/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,127,905 | 2,876,846 | 76,634,000 | 75,592,000 | $24.50 |
| 06/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 251,059 | -560,124 | 1,042,000 | -8,303,000 | $4.15 |
| 03/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 811,183 | -1,119,907 | 9,345,000 | -9,927,000 | $11.52 |
| 12/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,931,090 | -293,627 | 19,272,000 | -9,783,000 | $9.98 |
| 09/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,224,717 | 45,630 | 29,055,000 | -13,612,000 | $13.06 |
| 06/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,179,087 | -262,293 | 42,667,000 | -9,261,000 | $19.58 |
| 03/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,441,380 | 1,162,261 | 51,928,000 | 13,900,000 | $21.27 |
| 12/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,279,119 | 395,139 | 38,028,000 | 18,872,000 | $29.73 |
| 09/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 883,980 | -252,512 | 19,156,000 | -6,188,000 | $21.67 |
| 06/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,136,492 | 158,791 | 25,344,000 | 10,463,000 | $22.30 |
| 03/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 977,701 | 45,181 | 14,881,000 | -6,530,000 | $15.22 |
| 12/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 932,520 | 214,980 | 21,411,000 | 5,919,000 | $22.96 |
| 09/30/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 717,540 | 113,164 | 15,492,000 | 2,196,000 | $21.59 |
| 06/30/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 604,376 | 131,990 | 13,296,000 | 348,000 | $22.00 |
| 03/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 472,386 | -12,637 | 12,948,000 | -89,000 | $27.41 |
| 12/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 485,023 | -199,049 | 13,037,000 | -6,917,000 | $26.88 |
| 09/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 684,072 | 481,187 | 19,954,000 | 13,610,000 | $29.17 |
| 06/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 202,885 | 105,591 | 6,344,000 | 3,516,000 | $31.27 |
| 12/31/2017 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 97,294 | 97,294 | 2,828,000 | 2,828,000 | $29.07 |
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