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Iguana Healthcare Management, LLC
> MDCO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2018 | MEDICINES CO /DE | MDCO | 70,000 | 10,000 | 2,306,000 | 666,000 | $32.94 |
| 12/31/2017 | MEDICINES CO /DE | MDCO | 60,000 | -40,000 | 1,640,000 | -2,064,000 | $27.33 |
| 09/30/2017 | MEDICINES CO /DE | MDCO | 100,000 | -50,000 | 3,704,000 | -1,998,000 | $37.04 |
| 06/30/2017 | MEDICINES CO /DE | MDCO | 150,000 | -100,000 | 5,702,000 | -6,523,000 | $38.01 |
| 03/31/2017 | MEDICINES CO /DE | MDCO | 250,000 | -25,000 | 12,225,000 | 2,891,000 | $48.90 |
| 12/31/2016 | MEDICINES CO /DE | MDCO | 275,000 | 75,000 | 9,334,000 | 1,786,000 | $33.94 |
| 09/30/2016 | MEDICINES CO /DE | MDCO | 200,000 | 140,000 | 7,548,000 | 5,530,000 | $37.74 |
| 06/30/2016 | MEDICINES CO /DE | MDCO | 60,000 | 60,000 | 2,018,000 | 2,018,000 | $33.63 |
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