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PARAMETRIC PORTFOLIO ASSOCIATES LLC
> EPZM
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2022 | Epizyme, Inc. | EPZM | 24,475 | -110,449 | 28,000 | -309,000 | $1.14 |
| 12/31/2021 | Epizyme, Inc. | EPZM | 134,924 | 69,471 | 337,000 | 2,000 | $2.50 |
| 09/30/2021 | Epizyme, Inc. | EPZM | 65,453 | 7,831 | 335,000 | -144,000 | $5.12 |
| 06/30/2021 | Epizyme, Inc. | EPZM | 57,622 | 18,332 | 479,000 | 137,000 | $8.31 |
| 03/31/2021 | Epizyme, Inc. | EPZM | 39,290 | 15,678 | 342,000 | 86,000 | $8.70 |
| 12/31/2020 | Epizyme, Inc. | EPZM | 23,612 | 5,394 | 256,000 | 39,000 | $10.84 |
| 09/30/2020 | Epizyme, Inc. | EPZM | 18,218 | -31,831 | 217,000 | -587,000 | $11.91 |
| 06/30/2020 | Epizyme, Inc. | EPZM | 50,049 | -21,674 | 804,000 | -308,000 | $16.06 |
| 03/31/2020 | Epizyme, Inc. | EPZM | 71,723 | -1,100 | 1,112,000 | -679,000 | $15.50 |
| 12/31/2019 | Epizyme, Inc. | EPZM | 72,823 | 72,823 | 1,791,000 | 1,791,000 | $24.59 |
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