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PARAMETRIC PORTFOLIO ASSOCIATES LLC
> DRRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2022 | DURECT CORP | DRRX | 18,537 | 0 | 12,000 | -6,000 | $0.65 |
| 12/31/2021 | DURECT CORP | DRRX | 18,537 | -129 | 18,000 | -6,000 | $0.97 |
| 09/30/2021 | DURECT CORP | DRRX | 18,666 | -62,976 | 24,000 | -109,000 | $1.29 |
| 06/30/2021 | DURECT CORP | DRRX | 81,642 | 4,572 | 133,000 | -20,000 | $1.63 |
| 03/31/2021 | DURECT CORP | DRRX | 77,070 | 2,305 | 153,000 | -2,000 | $1.99 |
| 12/31/2020 | DURECT CORP | DRRX | 74,765 | -572,410 | 155,000 | -952,000 | $2.07 |
| 09/30/2020 | DURECT CORP | DRRX | 647,175 | -77,358 | 1,107,000 | -574,000 | $1.71 |
| 06/30/2020 | DURECT CORP | DRRX | 724,533 | 10,508 | 1,681,000 | 574,000 | $2.32 |
| 03/31/2020 | DURECT CORP | DRRX | 714,025 | 714,025 | 1,107,000 | 1,107,000 | $1.55 |
| 12/31/2018 | DURECT CORP | DRRX | 0 | -72,221 | 0 | -79,000 | |
| 09/30/2018 | DURECT CORP | DRRX | 72,221 | 52,599 | 79,000 | 48,000 | $1.09 |
| 06/30/2018 | DURECT CORP | DRRX | 19,622 | 19,622 | 31,000 | 31,000 | $1.58 |
| 09/30/2011 | DURECT CORP | DRRX | 0 | -17,351 | 0 | -62,464 | |
| 03/31/2011 | DURECT CORP | DRRX | 17,351 | 1,611 | 62,464 | 8,161 | $3.60 |
| 12/31/2010 | DURECT CORP | DRRX | 15,740 | 576 | 54,303 | 15,786 | $3.45 |
| 09/30/2010 | DURECT CORP | DRRX | 15,164 | -3,631 | 38,517 | -7,155 | $2.54 |
| 06/30/2010 | DURECT CORP | DRRX | 18,795 | 4,216 | 45,672 | 1,789 | $2.43 |
| 03/31/2010 | DURECT CORP | DRRX | 14,579 | 1,370 | 43,883 | 11,257 | $3.01 |
| 12/31/2009 | DURECT CORP | DRRX | 13,209 | 2,890 | 32,626 | 5,075 | $2.47 |
| 09/30/2009 | DURECT CORP | DRRX | 10,319 | -342 | 27,552 | 2,179 | $2.67 |
| 06/30/2009 | DURECT CORP | DRRX | 10,661 | -85,046 | 25,373 | -477,089 | $2.38 |
| 03/31/2008 | DURECT CORP | DRRX | 95,707 | -4,940 | 502,462 | -144,698 | $5.25 |
| 12/31/2007 | DURECT CORP | DRRX | 100,647 | 100,647 | 647,160 | 647,160 | $6.43 |
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