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D. E. Shaw & Co., Inc.
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 597,759 | 289,800 | 1,069,989,000 | 22,928,000 | $1,790.00 |
| 12/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 307,959 | 164,153 | 1,047,061,000 | 1,046,276,000 | $3,400.00 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 143,806 | 85,306 | 785,000 | 521,000 | $5.46 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 58,500 | 24,387 | 264,000 | 13,000 | $4.51 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 34,113 | -141,938 | 251,000 | -881,000 | $7.36 |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 176,051 | 176,051 | 1,132,000 | 1,132,000 | $6.43 |
| 06/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 0 | -14,865 | 0 | -156,000 | |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 14,865 | -1,367,268 | 156,000 | -21,240,000 | $10.49 |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 1,382,133 | -1,005,337 | 21,396,000 | -13,461,000 | $15.48 |
| 09/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 2,387,470 | -587,545 | 34,857,000 | -21,490,000 | $14.60 |
| 06/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 2,975,015 | 571,235 | 56,347,000 | 10,170,000 | $18.94 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 2,403,780 | 38,269 | 46,177,000 | 831,000 | $19.21 |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 2,365,511 | 984,484 | 45,346,000 | 32,061,000 | $19.17 |
| 09/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 1,381,027 | 575,565 | 13,285,000 | 8,461,000 | $9.62 |
| 06/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 805,462 | 359,087 | 4,824,000 | 2,218,000 | $5.99 |
| 03/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 446,375 | 276,707 | 2,606,000 | 1,016,000 | $5.84 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 169,668 | -53,595 | 1,590,000 | -2,212,000 | $9.37 |
| 09/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 223,263 | 51,751 | 3,802,000 | 888,000 | $17.03 |
| 06/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 171,512 | -4,029 | 2,914,000 | 558,000 | $16.99 |
| 03/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 175,541 | 102,770 | 2,356,000 | 1,657,000 | $13.42 |
| 12/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 72,771 | 12,222 | 699,000 | 34,000 | $9.61 |
| 09/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 60,549 | -14,124 | 665,000 | -11,000 | $10.98 |
| 06/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 74,673 | -71,092 | 676,000 | -1,196,000 | $9.05 |
| 03/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 145,765 | 104,495 | 1,872,000 | 1,485,000 | $12.84 |
| 12/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 41,270 | 13,051 | 387,000 | 112,000 | $9.38 |
| 09/30/2016 | Karyopharm Therapeutics Inc. | KPTI | 28,219 | 28,219 | 275,000 | 275,000 | $9.75 |
| 03/31/2016 | Karyopharm Therapeutics Inc. | KPTI | 0 | -47,700 | 0 | -632,000 | |
| 12/31/2015 | Karyopharm Therapeutics Inc. | KPTI | 47,700 | 47,700 | 632,000 | 632,000 | $13.25 |
| 09/30/2015 | Karyopharm Therapeutics Inc. | KPTI | 48,700 | 48,700 | 513,000 | 513,000 | $10.53 |
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