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Nuveen Asset Management, LLC
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 156,036 | -205,156 | 4,418,939,000 | 4,410,643,000 | $28,320.00 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 361,192 | -9,536 | 8,296,000 | -2,115,000 | $22.97 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 370,728 | 75,074 | 10,411,000 | 2,050,000 | $28.08 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 295,654 | -62,322 | 8,361,000 | 425,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 357,976 | -69,407 | 7,936,000 | -4,257,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 427,383 | -907 | 12,193,000 | -7,572,000 | $28.53 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 428,290 | -111,192 | 19,765,000 | -9,966,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 539,482 | 155,696 | 29,731,000 | 9,912,000 | $55.11 |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 383,786 | -43,775 | 19,819,000 | 1,293,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 427,561 | 54,487 | 18,526,000 | 5,469,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 373,074 | -43,409 | 13,057,000 | -9,216,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 416,483 | -1,862 | 22,273,000 | 7,431,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 418,345 | 70,583 | 14,842,000 | -1,764,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 347,762 | 108,469 | 16,606,000 | 8,852,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 239,293 | 13,629 | 7,754,000 | -3,502,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 225,664 | 225,664 | 11,256,000 | 11,256,000 | $49.88 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -8,550 | 0 | -489,000 | |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 8,550 | 8,550 | 489,000 | 489,000 | $57.19 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -12,250 | 0 | -630,000 | |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,250 | 0 | 630,000 | -85,000 | $51.43 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,250 | -225 | 715,000 | 194,000 | $58.37 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,475 | 225 | 521,000 | -126,000 | $41.76 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,250 | 0 | 647,000 | 134,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,250 | 12,250 | 513,000 | 513,000 | $41.88 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 17,829 | 17,829 | 724,000 | 724,000 | $40.61 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 10,068 | 10,068 | 654,000 | 654,000 | $64.96 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 10,068 | 10,068 | 711,000 | 711,000 | $70.62 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 10,068 | 10,068 | 1,119,000 | 1,119,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 11,134 | 11,134 | 1,050,000 | 1,050,000 | $94.31 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 11,134 | 11,134 | 1,247,000 | 1,247,000 | $112.00 |
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