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TWO SIGMA ADVISERS, LP
> OMER
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | OMEROS CORP | OMER | 38,600 | -39,100 | 209,984,000 | -151,321,000 | $5,440.00 |
| 03/31/2023 | OMEROS CORP | OMER | 77,700 | -129,700 | 361,305,000 | -107,419,000 | $4,650.00 |
| 12/31/2022 | OMEROS CORP | OMER | 207,400 | -32,100 | 468,724,000 | 467,970,000 | $2,260.00 |
| 09/30/2022 | OMEROS CORP | OMER | 239,500 | -136,300 | 754,000 | -279,000 | $3.15 |
| 06/30/2022 | OMEROS CORP | OMER | 375,800 | 268,600 | 1,033,000 | 389,000 | $2.75 |
| 03/31/2022 | OMEROS CORP | OMER | 107,200 | -18,900 | 644,000 | -167,000 | $6.01 |
| 12/31/2021 | OMEROS CORP | OMER | 126,100 | -42,600 | 811,000 | -1,515,000 | $6.43 |
| 09/30/2021 | OMEROS CORP | OMER | 168,700 | 36,800 | 2,326,000 | 369,000 | $13.79 |
| 06/30/2021 | OMEROS CORP | OMER | 131,900 | 65,000 | 1,957,000 | 766,000 | $14.84 |
| 03/31/2021 | OMEROS CORP | OMER | 66,900 | 66,900 | 1,191,000 | 1,191,000 | $17.80 |
| 09/30/2020 | OMEROS CORP | OMER | 0 | -41,500 | 0 | -611,000 | |
| 06/30/2020 | OMEROS CORP | OMER | 41,500 | 14,800 | 611,000 | 254,000 | $14.72 |
| 03/31/2020 | OMEROS CORP | OMER | 26,700 | 26,700 | 357,000 | 357,000 | $13.37 |
| 09/30/2019 | OMEROS CORP | OMER | 0 | -38,400 | 0 | -602,000 | |
| 06/30/2019 | OMEROS CORP | OMER | 38,400 | -21,700 | 602,000 | -442,000 | $15.68 |
| 03/31/2019 | OMEROS CORP | OMER | 60,100 | 20,600 | 1,044,000 | 604,000 | $17.37 |
| 12/31/2018 | OMEROS CORP | OMER | 39,500 | 17,700 | 440,000 | -92,000 | $11.14 |
| 09/30/2018 | OMEROS CORP | OMER | 21,800 | -3,300 | 532,000 | 77,000 | $24.40 |
| 06/30/2018 | OMEROS CORP | OMER | 25,100 | 25,100 | 455,000 | 455,000 | $18.13 |
| 06/30/2016 | OMEROS CORP | OMER | 0 | -10,100 | 0 | -155,000 | |
| 03/31/2016 | OMEROS CORP | OMER | 10,100 | 10,100 | 155,000 | 155,000 | $15.35 |
| 12/31/2015 | OMEROS CORP | OMER | 0 | -18,400 | 0 | -259,000 | |
| 09/30/2015 | OMEROS CORP | OMER | 18,400 | 18,400 | 259,000 | 259,000 | $14.08 |
| 06/30/2015 | OMEROS CORP | OMER | 15,400 | -45,800 | 277,000 | -1,061,000 | $17.99 |
| 03/31/2015 | OMEROS CORP | OMER | 64,100 | 700 | 1,412,000 | -150,000 | $22.03 |
| 12/31/2014 | OMEROS CORP | OMER | 65,800 | 65,800 | 1,631,000 | 1,631,000 | $24.79 |
| 09/30/2014 | OMEROS CORP | OMER | 0 | -37,700 | 0 | -656,000 | |
| 06/30/2014 | OMEROS CORP | OMER | 37,700 | 37,700 | 656,000 | 656,000 | $17.40 |
| 12/31/2012 | OMEROS CORP | OMER | 0 | -43,100 | 0 | -405,000 | |
| 09/30/2012 | OMEROS CORP | OMER | 43,100 | 14,700 | 405,000 | 121,000 | $9.40 |
| 06/30/2012 | OMEROS CORP | OMER | 28,400 | 28,400 | 284,000 | 284,000 | $10.00 |
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