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INTERNATIONAL BIOTECHNOLOGY TRUST PLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 21,000 | -12,000 | 7,386,750,000 | -2,998,680,000 | $351,750.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 33,000 | 33,000 | 10,385,430,000 | 10,385,430,000 | $314,710.00 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -25,122 | 0 | -3,225,000 | |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 25,122 | -52,100 | 3,225,000 | -13,733,000 | $128.37 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 77,222 | 0 | 16,958,000 | 2,951,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 77,222 | -8,100 | 14,007,000 | -4,324,000 | $181.39 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 85,322 | -12,000 | 18,331,000 | -4,648,000 | $214.84 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 97,322 | 32,500 | 22,979,000 | 5,364,000 | $236.11 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 64,822 | 0 | 17,615,000 | -871,000 | $271.74 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 64,822 | -13,000 | 18,486,000 | -31,000 | $285.18 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 77,822 | -6,200 | 18,517,000 | 4,285,000 | $237.94 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 93,422 | 9,400 | 20,444,000 | 6,212,000 | $218.83 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 84,022 | -1,000 | 14,232,000 | -1,353,000 | $169.38 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 85,022 | 33,900 | 15,585,000 | 6,185,000 | $183.31 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 51,122 | -39,000 | 9,400,000 | -2,326,000 | $183.87 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 90,122 | 22,400 | 11,726,000 | 1,717,000 | $130.11 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 67,722 | -15,500 | 10,009,000 | -4,135,000 | $147.80 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 83,222 | 15,000 | 14,144,000 | 3,025,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 68,222 | -7,200 | 11,119,000 | -185,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 75,422 | -60,100 | 11,304,000 | -6,161,000 | $149.88 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 88,722 | -46,800 | 13,488,000 | -3,977,000 | $152.03 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 135,522 | 13,000 | 17,465,000 | 4,068,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 122,522 | 122,522 | 13,397,000 | 13,397,000 | $109.34 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 105,522 | 105,522 | 7,780,000 | 7,780,000 | $73.73 |
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