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CHARLES SCHWAB INVESTMENT MANAGEMENT INC
> OTIC
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2022 | OTONOMY, INC. | OTIC | 16,843 | 0 | 36,000 | -5,000 | $2.14 |
| 03/31/2022 | OTONOMY, INC. | OTIC | 16,843 | 0 | 41,000 | 5,000 | $2.43 |
| 12/31/2021 | OTONOMY, INC. | OTIC | 16,843 | 0 | 36,000 | -2,000 | $2.14 |
| 06/30/2021 | OTONOMY, INC. | OTIC | 16,843 | 0 | 38,000 | -5,000 | $2.26 |
| 03/31/2021 | OTONOMY, INC. | OTIC | 16,843 | 0 | 43,000 | -66,000 | $2.55 |
| 12/31/2020 | OTONOMY, INC. | OTIC | 16,843 | -15,000 | 109,000 | -20,000 | $6.47 |
| 09/30/2020 | OTONOMY, INC. | OTIC | 31,843 | 31,843 | 129,000 | 129,000 | $4.05 |
| 09/30/2019 | OTONOMY, INC. | OTIC | 0 | -17,686 | 0 | -49,000 | |
| 06/30/2019 | OTONOMY, INC. | OTIC | 17,686 | 0 | 49,000 | 2,000 | $2.77 |
| 03/31/2019 | OTONOMY, INC. | OTIC | 17,686 | 17,686 | 47,000 | 47,000 | $2.66 |
| 09/30/2018 | OTONOMY, INC. | OTIC | 0 | -81,750 | 0 | -315,000 | |
| 06/30/2018 | OTONOMY, INC. | OTIC | 81,750 | -32,866 | 315,000 | -167,000 | $3.85 |
| 03/31/2018 | OTONOMY, INC. | OTIC | 114,616 | 3,744 | 482,000 | -134,000 | $4.21 |
| 12/31/2017 | OTONOMY, INC. | OTIC | 110,872 | 110,872 | 616,000 | 616,000 | $5.56 |
| 09/30/2017 | OTONOMY, INC. | OTIC | 0 | -129,642 | 0 | -2,444,000 | |
| 06/30/2017 | OTONOMY, INC. | OTIC | 129,642 | 14,856 | 2,444,000 | 1,037,000 | $18.85 |
| 03/31/2017 | OTONOMY, INC. | OTIC | 114,786 | 6,798 | 1,407,000 | -311,000 | $12.26 |
| 12/31/2016 | OTONOMY, INC. | OTIC | 107,988 | 6,363 | 1,718,000 | -131,000 | $15.91 |
| 09/30/2016 | OTONOMY, INC. | OTIC | 101,625 | 63,186 | 1,849,000 | 1,238,000 | $18.19 |
| 06/30/2016 | OTONOMY, INC. | OTIC | 38,439 | 38,439 | 611,000 | 611,000 | $15.90 |
| 03/31/2016 | OTONOMY, INC. | OTIC | 30,139 | 9,100 | 450,000 | -134,000 | $14.93 |
| 12/31/2015 | OTONOMY, INC. | OTIC | 21,039 | 0 | 584,000 | 209,000 | $27.76 |
| 09/30/2015 | OTONOMY, INC. | OTIC | 21,039 | 21,039 | 375,000 | 375,000 | $17.82 |
| 06/30/2015 | OTONOMY, INC. | OTIC | 21,039 | 10,539 | 484,000 | 112,000 | $23.00 |
| 03/31/2015 | OTONOMY, INC. | OTIC | 10,500 | 10,500 | 372,000 | 372,000 | $35.43 |
| 12/31/2014 | OTONOMY, INC. | OTIC | 10,500 | 10,500 | 350,000 | 350,000 | $33.33 |
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