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OXFORD ASSET MANAGEMENT LLP
> MDCO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2020 | MEDICINES CO /DE | MDCO | 0 | -271,046 | 0 | -23,023,000 | |
| 12/31/2019 | MEDICINES CO /DE | MDCO | 271,046 | 271,046 | 23,023,000 | 23,023,000 | $84.94 |
| 12/31/2018 | MEDICINES CO /DE | MDCO | 0 | -10,149 | 0 | -296,000 | |
| 09/30/2018 | MEDICINES CO /DE | MDCO | 10,149 | 10,149 | 296,000 | 296,000 | $29.17 |
| 12/31/2015 | MEDICINES CO /DE | MDCO | 0 | -63,159 | 0 | -2,398,000 | |
| 09/30/2015 | MEDICINES CO /DE | MDCO | 63,159 | 63,159 | 2,398,000 | 2,398,000 | $37.97 |
| 03/31/2015 | MEDICINES CO /DE | MDCO | 0 | -361,991 | 0 | -9,971,000 | |
| 12/31/2014 | MEDICINES CO /DE | MDCO | 0 | -314,961 | 0 | -7,155,000 | |
| 09/30/2014 | MEDICINES CO /DE | MDCO | 314,961 | 314,961 | 7,155,000 | 7,155,000 | $22.72 |
| 12/31/2013 | MEDICINES CO /DE | MDCO | 0 | -47,556 | 0 | -1,594,000 | |
| 09/30/2013 | MEDICINES CO /DE | MDCO | 47,556 | 47,556 | 1,594,000 | 1,594,000 | $33.52 |
| 06/30/2013 | MEDICINES CO /DE | MDCO | 0 | -149,049 | 0 | -4,981,000 | |
| 03/31/2013 | MEDICINES CO /DE | MDCO | 149,049 | 39,730 | 4,981,000 | 2,361,000 | $33.42 |
| 12/31/2012 | MEDICINES CO /DE | MDCO | 109,319 | 109,319 | 2,620,000 | 2,620,000 | $23.97 |
| 03/31/2012 | MEDICINES CO /DE | MDCO | 0 | -104,723 | 0 | -1,952,000 | |
| 12/31/2011 | MEDICINES CO /DE | MDCO | 104,723 | 104,723 | 1,952,000 | 1,952,000 | $18.64 |
| 09/30/2011 | MEDICINES CO /DE | MDCO | 0 | -107,259 | 0 | -1,771,000 | |
| 06/30/2011 | MEDICINES CO /DE | MDCO | 107,259 | -53,817 | 1,771,000 | -853,000 | $16.51 |
| 03/31/2011 | MEDICINES CO /DE | MDCO | 161,076 | -130,739 | 2,624,000 | -1,499,000 | $16.29 |
| 12/31/2010 | MEDICINES CO /DE | MDCO | 291,815 | -34,135 | 4,123,000 | -505,000 | $14.13 |
| 09/30/2010 | MEDICINES CO /DE | MDCO | 325,950 | 245,991 | 4,628,000 | 4,020,000 | $14.20 |
| 06/30/2010 | MEDICINES CO /DE | MDCO | 79,959 | -6,133 | 608,000 | -67,000 | $7.60 |
| 03/31/2010 | MEDICINES CO /DE | MDCO | 86,092 | 86,092 | 675,000 | 675,000 | $7.84 |
| 09/30/2009 | MEDICINES CO /DE | MDCO | 0 | -169,938 | 0 | -1,426,000 | |
| 06/30/2009 | MEDICINES CO /DE | MDCO | 169,938 | 110,038 | 1,426,000 | 544,000 | $8.39 |
| 03/31/2009 | MEDICINES CO /DE | MDCO | 0 | -59,900 | 0 | -882,000 | |
| 12/31/2008 | MEDICINES CO /DE | MDCO | 59,900 | 22,800 | 882,000 | 21,000 | $14.72 |
| 09/30/2008 | MEDICINES CO /DE | MDCO | 37,100 | 37,100 | 861,000 | 861,000 | $23.21 |
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