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RATIONAL ADVISORS LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 382 | 382 | 134,430,000 | 134,430,000 | $351,910.99 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -23 | 0 | -6,000 | |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 23 | 4 | 6,000 | 0 | $260.87 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19 | 19 | 6,000 | 6,000 | $315.79 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -927 | 0 | -203,000 | |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 927 | 833 | 203,000 | 187,000 | $218.99 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 94 | -4,249 | 16,000 | -781,000 | $170.21 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,343 | 1,517 | 797,000 | 277,000 | $183.51 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,826 | 2,826 | 520,000 | 520,000 | $184.01 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -104 | 0 | -20,000 | |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 104 | 100 | 20,000 | 19,000 | $192.31 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4 | -82 | 1,000 | -13,000 | $250.00 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 86 | 86 | 14,000 | 14,000 | $162.79 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -54 | 0 | -6,000 | |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 54 | 54 | 6,000 | 6,000 | $111.11 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 54 | 0 | 7,000 | 1,000 | $129.63 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 54 | 54 | 6,000 | 6,000 | $111.11 |
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