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Apex Capital Management
> ISIS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | ISIS | 0 | -1,019,618 | 0 | -41,213,000 | |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | ISIS | 0 | -1,019,618 | 0 | -41,213,000 | |
| 09/30/2015 | IONIS PHARMACEUTICALS INC | ISIS | 1,019,618 | 945,534 | 41,213,000 | 40,391,000 | $40.42 |
| 06/30/2015 | IONIS PHARMACEUTICALS INC | ISIS | 980,129 | 92,610 | 56,406,000 | 1,611,000 | $57.55 |
| 03/31/2015 | IONIS PHARMACEUTICALS INC | ISIS | 928,654 | 41,135 | 59,127,000 | 4,332,000 | $63.67 |
| 12/31/2014 | IONIS PHARMACEUTICALS INC | ISIS | 887,519 | 813,435 | 54,795,000 | 53,973,000 | $61.74 |
| 09/30/2014 | IONIS PHARMACEUTICALS INC | ISIS | 843,791 | 128,474 | 32,764,000 | 1,855,000 | $38.83 |
| 06/30/2014 | IONIS PHARMACEUTICALS INC | ISIS | 889,545 | 174,228 | 30,645,000 | -264,000 | $34.45 |
| 03/31/2014 | IONIS PHARMACEUTICALS INC | ISIS | 715,317 | 641,233 | 30,909,000 | 30,087,000 | $43.21 |
| 12/31/2013 | IONIS PHARMACEUTICALS INC | ISIS | 757,910 | 683,826 | 30,195,000 | 29,373,000 | $39.84 |
| 03/31/2010 | IONIS PHARMACEUTICALS INC | ISIS | 0 | -74,084 | 0 | -822,000 | |
| 12/31/2009 | IONIS PHARMACEUTICALS INC | ISIS | 74,084 | 872 | 822,000 | -245,000 | $11.10 |
| 09/30/2009 | IONIS PHARMACEUTICALS INC | ISIS | 73,212 | 31,661 | 1,067,000 | -228,000 | $14.57 |
| 06/30/2009 | IONIS PHARMACEUTICALS INC | ISIS | 41,551 | -21,053 | 1,295,000 | 355,000 | $31.17 |
| 03/31/2009 | IONIS PHARMACEUTICALS INC | ISIS | 62,604 | -46,347 | 940,000 | -605,000 | $15.02 |
| 12/31/2008 | IONIS PHARMACEUTICALS INC | ISIS | 108,951 | 108,951 | 1,545,000 | 1,545,000 | $14.18 |
| 09/30/2008 | IONIS PHARMACEUTICALS INC | ISIS | 95,758 | 11,825 | 1,617,000 | 473,000 | $16.89 |
| 06/30/2008 | IONIS PHARMACEUTICALS INC | ISIS | 83,933 | 6,352 | 1,144,000 | 49,000 | $13.63 |
| 03/31/2008 | IONIS PHARMACEUTICALS INC | ISIS | 77,581 | 52,680 | 1,095,000 | 703,000 | $14.11 |
| 12/31/2007 | IONIS PHARMACEUTICALS INC | ISIS | 24,901 | 24,901 | 392,000 | 392,000 | $15.74 |
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