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TWO SIGMA INVESTMENTS, LP
> HBIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | HARVARD BIOSCIENCE INC | HBIO | 120,124 | 51,538 | 659,481,000 | 371,420,000 | $5,490.00 |
| 03/31/2023 | HARVARD BIOSCIENCE INC | HBIO | 68,586 | -61,256 | 288,061,000 | -71,601,000 | $4,200.00 |
| 12/31/2022 | HARVARD BIOSCIENCE INC | HBIO | 129,842 | 30,319 | 359,662,000 | 359,304,000 | $2,770.00 |
| 06/30/2022 | HARVARD BIOSCIENCE INC | HBIO | 99,523 | 46,835 | 358,000 | 31,000 | $3.60 |
| 03/31/2022 | HARVARD BIOSCIENCE INC | HBIO | 52,688 | -84,373 | 327,000 | -639,000 | $6.21 |
| 12/31/2021 | HARVARD BIOSCIENCE INC | HBIO | 137,061 | -79,083 | 966,000 | -543,000 | $7.05 |
| 09/30/2021 | HARVARD BIOSCIENCE INC | HBIO | 216,144 | -43,940 | 1,509,000 | -657,000 | $6.98 |
| 06/30/2021 | HARVARD BIOSCIENCE INC | HBIO | 260,084 | 121,165 | 2,166,000 | 1,408,000 | $8.33 |
| 03/31/2021 | HARVARD BIOSCIENCE INC | HBIO | 138,919 | 38,936 | 758,000 | 329,000 | $5.46 |
| 12/31/2020 | HARVARD BIOSCIENCE INC | HBIO | 99,983 | 44,969 | 429,000 | 263,000 | $4.29 |
| 09/30/2020 | HARVARD BIOSCIENCE INC | HBIO | 55,014 | 4,100 | 166,000 | 8,000 | $3.02 |
| 06/30/2020 | HARVARD BIOSCIENCE INC | HBIO | 50,914 | -19,201 | 158,000 | 3,000 | $3.10 |
| 03/31/2020 | HARVARD BIOSCIENCE INC | HBIO | 70,115 | -100,992 | 155,000 | -367,000 | $2.21 |
| 12/31/2019 | HARVARD BIOSCIENCE INC | HBIO | 171,107 | -96,979 | 522,000 | -302,000 | $3.05 |
| 09/30/2019 | HARVARD BIOSCIENCE INC | HBIO | 268,086 | 29,134 | 824,000 | 346,000 | $3.07 |
| 06/30/2019 | HARVARD BIOSCIENCE INC | HBIO | 238,952 | 189,205 | 478,000 | 264,000 | $2.00 |
| 03/31/2019 | HARVARD BIOSCIENCE INC | HBIO | 49,747 | -33,555 | 214,000 | -51,000 | $4.30 |
| 12/31/2018 | HARVARD BIOSCIENCE INC | HBIO | 83,302 | -49,228 | 265,000 | -431,000 | $3.18 |
| 09/30/2018 | HARVARD BIOSCIENCE INC | HBIO | 132,530 | 132,530 | 696,000 | 696,000 | $5.25 |
| 09/30/2017 | HARVARD BIOSCIENCE INC | HBIO | 0 | -10,404 | 0 | -27,000 | |
| 06/30/2017 | HARVARD BIOSCIENCE INC | HBIO | 10,404 | -300 | 27,000 | -1,000 | $2.60 |
| 03/31/2017 | HARVARD BIOSCIENCE INC | HBIO | 10,704 | -100 | 28,000 | -5,000 | $2.62 |
| 12/31/2016 | HARVARD BIOSCIENCE INC | HBIO | 10,804 | -100 | 33,000 | 3,000 | $3.05 |
| 09/30/2016 | HARVARD BIOSCIENCE INC | HBIO | 10,904 | -100 | 30,000 | -1,000 | $2.75 |
| 06/30/2016 | HARVARD BIOSCIENCE INC | HBIO | 11,004 | -1,400 | 31,000 | -6,000 | $2.82 |
| 03/31/2016 | HARVARD BIOSCIENCE INC | HBIO | 12,404 | -3,186 | 37,000 | -37,000 | $2.98 |
| 12/31/2015 | HARVARD BIOSCIENCE INC | HBIO | 46,821 | 28,080 | 162,000 | 55,000 | $3.46 |
| 09/30/2015 | HARVARD BIOSCIENCE INC | HBIO | 10,073 | -8,668 | 38,000 | -69,000 | $3.77 |
| 06/30/2015 | HARVARD BIOSCIENCE INC | HBIO | 18,741 | 3,151 | 107,000 | 33,000 | $5.71 |
| 03/31/2015 | HARVARD BIOSCIENCE INC | HBIO | 26,541 | 10,951 | 154,000 | 80,000 | $5.80 |
| 12/31/2014 | HARVARD BIOSCIENCE INC | HBIO | 26,541 | 10,951 | 150,000 | 76,000 | $5.65 |
| 09/30/2014 | HARVARD BIOSCIENCE INC | HBIO | 37,197 | 21,607 | 152,000 | 78,000 | $4.09 |
| 06/30/2014 | HARVARD BIOSCIENCE INC | HBIO | 71,196 | 55,606 | 324,000 | 250,000 | $4.55 |
| 03/31/2014 | HARVARD BIOSCIENCE INC | HBIO | 23,445 | 7,855 | 111,000 | 37,000 | $4.73 |
| 12/31/2013 | HARVARD BIOSCIENCE INC | HBIO | 0 | -15,300 | 0 | -80,000 | |
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