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TWO SIGMA INVESTMENTS, LP
> SPRB
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | 228,130 | 64,965 | 490,480,000 | 129,885,000 | $2,150.00 |
| 03/31/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | 163,165 | 163,165 | 360,595,000 | 360,595,000 | $2,210.00 |
| 12/31/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 0 | -29,392 | 0 | -177,000 | |
| 09/30/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 29,392 | 17,417 | 177,000 | 43,000 | $6.02 |
| 06/30/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | 11,975 | 11,975 | 134,000 | 134,000 | $11.19 |
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