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TWO SIGMA INVESTMENTS, LP
> MIST
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Milestone Pharmaceuticals Inc. | MIST | 52,186 | 16,879 | 148,730,000 | 9,620,000 | $2,850.00 |
| 03/31/2023 | Milestone Pharmaceuticals Inc. | MIST | 35,307 | -159,036 | 139,110,000 | -630,488,000 | $3,940.01 |
| 12/31/2022 | Milestone Pharmaceuticals Inc. | MIST | 194,343 | 194,343 | 769,598,000 | 769,598,000 | $3,960.00 |
| 09/30/2021 | Milestone Pharmaceuticals Inc. | MIST | 0 | -16,235 | 0 | -89,000 | |
| 06/30/2021 | Milestone Pharmaceuticals Inc. | MIST | 16,235 | -38,578 | 89,000 | -228,000 | $5.48 |
| 03/31/2021 | Milestone Pharmaceuticals Inc. | MIST | 54,813 | -2,598 | 317,000 | -68,000 | $5.78 |
| 12/31/2020 | Milestone Pharmaceuticals Inc. | MIST | 57,411 | 37,509 | 385,000 | 239,000 | $6.71 |
| 09/30/2020 | Milestone Pharmaceuticals Inc. | MIST | 19,902 | 19,902 | 146,000 | 146,000 | $7.34 |
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